The relationship between self-reported immune fitness and salivary immune biomarker concentrations.

IF 3.3 4区 医学 Q3 IMMUNOLOGY
Emina Išerić, Pauline A Hendriksen, Guusje A Ulijn, Marit Zuurveld, Aurora Jae van de Loo, Johan Garssen, Joris C Verster
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Abstract

Immune fitness refers to the body's ability to respond to health challenges by activating an appropriate immune response. Perceived immune fitness can be assessed using a single-item scale ranging from 0 (very poor) to 10 (excellent). The aim of the current study (n = 29 healthy volunteers) was to evaluate the relationship between perceived immune fitness and immune biomarker concentrations in saliva. Hourly assessments of immune fitness were made throughout the day (09:30 - 15:30), and saliva samples were collected accordingly. The concentrations of interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor-alpha (TNF-α) were determined using multiplex immunoassay. While immune fitness scores remained stable during the day, biomarker assessments showed some fluctuations. For IL-6, significant negative correlations were found between IL-6 concentration at 10:30 and immune fitness scores at 10:30 (r = -0.512), 11:30 (r = -0.383), and 12:30 (r = -0.443), and between the IL-6 concentration and immune fitness score at 15:30 (r = -0.704). For IL-8, significant correlations were found between IL-8 concentration at 10:30 and immune fitness scores at 10:30 (r = -0.480), 12:30 (r = -0.456), and 14:30 (r = -0.429). For TNF-α, significant positive correlations were found between TNF-α concentration at 13:30 and immune fitness scores at 13:30 (r = 0.517) and 14:30 (r = 0.477). No significant correlations were found between immune fitness and IL-1β. In conclusion, immune fitness scores remained stable throughout the day, and were significantly associated with salivary concentrations of IL-6, IL-8, and TNF-α at certain time points.

自我报告的免疫适应性与唾液免疫生物标志物浓度的关系。
免疫适应性是指人体通过激活适当的免疫反应来应对健康挑战的能力。感知免疫适应度可使用单项量表进行评估,范围从0(极差)到10(极好)。本研究(29名健康志愿者)的目的是评估感知免疫适应性与唾液中免疫生物标志物浓度之间的关系。全天(09:30 - 15:30)每小时进行一次免疫适应性评估,并相应地收集唾液样本。采用多重免疫分析法测定白细胞介素(IL)-1β、IL-6、IL-8和肿瘤坏死因子-α (TNF-α)的浓度。虽然免疫适应性评分在白天保持稳定,但生物标志物评估显示出一些波动。对于IL-6, 10点30分IL-6浓度与免疫适应性评分在10点30分(r = -0.512)、11点30分(r = -0.383)和12点30分(r = -0.443)呈显著负相关,在15点30分IL-6浓度与免疫适应性评分在15点30分IL-6浓度与免疫适应性评分之间呈显著负相关(r = -0.704)。对于IL-8, 10:30时IL-8浓度与免疫适应性评分在10:30 (r = -0.480)、12:30 (r = -0.456)和14:30 (r = -0.429)呈显著相关。对于TNF-α, 13:30的TNF-α浓度与13:30和14:30的免疫适应性评分呈显著正相关(r = 0.517), r = 0.477。免疫适应度与IL-1β之间无显著相关性。综上所述,免疫适应性评分全天保持稳定,且在特定时间点与唾液中IL-6、IL-8和TNF-α浓度显著相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Immunologic Research
Immunologic Research 医学-免疫学
CiteScore
6.90
自引率
0.00%
发文量
83
审稿时长
6-12 weeks
期刊介绍: IMMUNOLOGIC RESEARCH represents a unique medium for the presentation, interpretation, and clarification of complex scientific data. Information is presented in the form of interpretive synthesis reviews, original research articles, symposia, editorials, and theoretical essays. The scope of coverage extends to cellular immunology, immunogenetics, molecular and structural immunology, immunoregulation and autoimmunity, immunopathology, tumor immunology, host defense and microbial immunity, including viral immunology, immunohematology, mucosal immunity, complement, transplantation immunology, clinical immunology, neuroimmunology, immunoendocrinology, immunotoxicology, translational immunology, and history of immunology.
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