In vitro flow properties of Preserflo Michroshunt with an intraluminal stent.

IF 2.8 3区医学 Q1 OPHTHALMOLOGY

Eye Pub Date : 2025-06-11 DOI:10.1038/s41433-025-03870-7

Enrico Lupardi, Antonio Cassiano, Antonio Moramarco, Luigi Fontana, Ivan Corazza, Keith Barton

{"title":"In vitro flow properties of Preserflo Michroshunt with an intraluminal stent.","authors":"Enrico Lupardi, Antonio Cassiano, Antonio Moramarco, Luigi Fontana, Ivan Corazza, Keith Barton","doi":"10.1038/s41433-025-03870-7","DOIUrl":null,"url":null,"abstract":"Objectives: This study aimed to evaluate the impact of varying stent sizes and materials on the outflow of the Preserflo Microshunt (PMS).Methods: In vitro experiments were conducted using five new PMS samples. Intraluminal stents of two materials (nylon and polypropylene) and two sizes (9-0 and 10-0) were tested. Flow was measured using a balanced saline solution (BSS) under a constant hydrostatic pressure, and the resistance was calculated. Theoretical calculations based on the Hagen-Poiseuille law were compared with in vitro results, and the results were corrected to calculate resistance to flow using aqueous humour properties. Five measurements were obtained for each material and size.Results: Without any stent, the median resistance internal to PMS corrected for aqueous humour viscosity was 1.59 mmHg/µL/min. Median resistances were 6.35 mmHg/µL/min (range: 3.88-7.42) for the 10-0 nylon and, 11.79 mmHg/µL/min (range: 7.08-13.71) for the 10-0 polypropylene. The 9-0 stents showed higher resistance: 10.99 mmHg/µL/min (range: 7.34-22.75) for 9-0 nylon, finally, the 9-0 polypropylene resulted in a resistance of 37.55 mmHg/µL/min (range: 36.52-38.41).Conclusions: This study indicates that the tested suture materials and sizes have a significant impact on the outflow resistance of the PMS device. Larger sutures and/or polypropylene materials seem to offer more resistance to aqueous outflow.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Eye","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41433-025-03870-7","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: This study aimed to evaluate the impact of varying stent sizes and materials on the outflow of the Preserflo Microshunt (PMS).

Methods: In vitro experiments were conducted using five new PMS samples. Intraluminal stents of two materials (nylon and polypropylene) and two sizes (9-0 and 10-0) were tested. Flow was measured using a balanced saline solution (BSS) under a constant hydrostatic pressure, and the resistance was calculated. Theoretical calculations based on the Hagen-Poiseuille law were compared with in vitro results, and the results were corrected to calculate resistance to flow using aqueous humour properties. Five measurements were obtained for each material and size.

Results: Without any stent, the median resistance internal to PMS corrected for aqueous humour viscosity was 1.59 mmHg/µL/min. Median resistances were 6.35 mmHg/µL/min (range: 3.88-7.42) for the 10-0 nylon and, 11.79 mmHg/µL/min (range: 7.08-13.71) for the 10-0 polypropylene. The 9-0 stents showed higher resistance: 10.99 mmHg/µL/min (range: 7.34-22.75) for 9-0 nylon, finally, the 9-0 polypropylene resulted in a resistance of 37.55 mmHg/µL/min (range: 36.52-38.41).

Conclusions: This study indicates that the tested suture materials and sizes have a significant impact on the outflow resistance of the PMS device. Larger sutures and/or polypropylene materials seem to offer more resistance to aqueous outflow.

查看原文本刊更多论文

Preserflo微分流器与腔内支架的体外流动特性。

目的：本研究旨在评估不同支架尺寸和材料对Preserflo Microshunt （PMS）流出的影响。方法：采用5种新的PMS样品进行体外实验。我们测试了两种材料（尼龙和聚丙烯）和两种尺寸（9-0和10-0）的腔内支架。用平衡盐水溶液（BSS）在恒定静水压力下测量流量，并计算阻力。将基于Hagen-Poiseuille定律的理论计算结果与体外实验结果进行了比较，并对结果进行了修正，以利用水相性质计算流动阻力。对每种材料和尺寸进行了五次测量。结果：在没有任何支架的情况下，经水黏度校正的PMS内阻力中位数为1.59 mmHg/µL/min。10-0尼龙的中位电阻为6.35 mmHg/µL/min（范围：3.88-7.42），10-0聚丙烯的中位电阻为11.79 mmHg/µL/min（范围：7.08-13.71）。9-0尼龙支架阻力较大，为10.99 mmHg/µL/min（范围：7.34-22.75），9-0聚丙烯支架阻力较大，为37.55 mmHg/µL/min（范围：36.52-38.41）。结论：本研究表明，所测试的缝线材料和尺寸对PMS装置的流出阻力有显著影响。较大的缝合线和/或聚丙烯材料似乎对水流出有更大的阻力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Eye 医学-眼科学

CiteScore

6.40

自引率

5.10%

发文量

481

审稿时长

3-6 weeks

期刊介绍： Eye seeks to provide the international practising ophthalmologist with high quality articles, of academic rigour, on the latest global clinical and laboratory based research. Its core aim is to advance the science and practice of ophthalmology with the latest clinical- and scientific-based research. Whilst principally aimed at the practising clinician, the journal contains material of interest to a wider readership including optometrists, orthoptists, other health care professionals and research workers in all aspects of the field of visual science worldwide. Eye is the official journal of The Royal College of Ophthalmologists. Eye encourages the submission of original articles covering all aspects of ophthalmology including: external eye disease; oculo-plastic surgery; orbital and lacrimal disease; ocular surface and corneal disorders; paediatric ophthalmology and strabismus; glaucoma; medical and surgical retina; neuro-ophthalmology; cataract and refractive surgery; ocular oncology; ophthalmic pathology; ophthalmic genetics.