Hidradenitis suppurativa in pediatric patients with Down Syndrome: a comparative study of 116 cases and controls.

IF 3.7 4区医学 Q1 DERMATOLOGY

Clinical and Experimental Dermatology Pub Date : 2025-06-11 DOI:10.1093/ced/llaf256

Maria Sin-Soler, Magdalini Louka, Patricia Garbayo-Salmons, Antonio Torrelo, Angela Hernández-Martín, Lucero Noguera-Morel

{"title":"Hidradenitis suppurativa in pediatric patients with Down Syndrome: a comparative study of 116 cases and controls.","authors":"Maria Sin-Soler, Magdalini Louka, Patricia Garbayo-Salmons, Antonio Torrelo, Angela Hernández-Martín, Lucero Noguera-Morel","doi":"10.1093/ced/llaf256","DOIUrl":null,"url":null,"abstract":"Background: Hidradenitis suppurativa (HS) seems to be more prevalent in patients with Down syndrome (DS), with earlier onset, higher incidence in females, and increased body mass index (BMI) in these individuals.Objectives: To describe the demographic, clinical characteristics, and severity of HS in children with DS and compare them to DS-non-HS patients.Methods: A retrospective, observational, 5-year study of children (<18 years) with DS at Hospital Infantil Universitario Niño Jesús.Results: HS was diagnosed in 32 of 116 DS patients. The median age at onset was 13 years, with 53.1% female, and a median BMI of 24.4kg/m². The most common phenotype was follicular (46.9%), and the majority (84.4%) had mild disease (Hurley I). The groin (75%) and buttocks (65.6%) were the most affected areas. Treatment mainly involved topical and oral antibiotics, with 9.4% undergoing surgery. Significant differences were observed across phenotypes in sex distribution, HS lesion location, and surgical rates. Compared to DS-non-HS patients, our data report higher BMI, and greater association with the follicular occlusion tetrad. The limitations of this study include its retrospective nature, small sample size, and data collected from a single center.Conclusions: HS in children with DS is characterized by an early onset, higher BMI, predominance of follicular phenotype, and mild severity.","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Experimental Dermatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/ced/llaf256","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DERMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Hidradenitis suppurativa (HS) seems to be more prevalent in patients with Down syndrome (DS), with earlier onset, higher incidence in females, and increased body mass index (BMI) in these individuals.

Objectives: To describe the demographic, clinical characteristics, and severity of HS in children with DS and compare them to DS-non-HS patients.

Methods: A retrospective, observational, 5-year study of children (<18 years) with DS at Hospital Infantil Universitario Niño Jesús.

Results: HS was diagnosed in 32 of 116 DS patients. The median age at onset was 13 years, with 53.1% female, and a median BMI of 24.4kg/m². The most common phenotype was follicular (46.9%), and the majority (84.4%) had mild disease (Hurley I). The groin (75%) and buttocks (65.6%) were the most affected areas. Treatment mainly involved topical and oral antibiotics, with 9.4% undergoing surgery. Significant differences were observed across phenotypes in sex distribution, HS lesion location, and surgical rates. Compared to DS-non-HS patients, our data report higher BMI, and greater association with the follicular occlusion tetrad. The limitations of this study include its retrospective nature, small sample size, and data collected from a single center.

Conclusions: HS in children with DS is characterized by an early onset, higher BMI, predominance of follicular phenotype, and mild severity.

查看原文本刊更多论文

小儿唐氏综合征化脓性汗腺炎116例与对照组比较研究

背景：化脓性汗腺炎（HS）似乎在唐氏综合征（DS）患者中更为普遍，发病较早，女性发病率较高，这些个体的体重指数（BMI）也较高。目的：描述DS患儿HS的人口学、临床特征和严重程度，并将其与DS-非HS患者进行比较。方法：回顾性观察5年儿童研究(结果：116例退行性椎体滑移患者中32例诊断为HS。发病年龄中位数为13岁，女性53.1%，BMI中位数为24.4kg/m²。最常见的表型为滤泡型（46.9%），大多数（84.4%）有轻度疾病（Hurley I型）。腹股沟（75%）和臀部（65.6%）是最主要的受累部位。治疗主要包括外用和口服抗生素，9.4%接受手术。不同表型在性别分布、HS病变位置和手术率上观察到显著差异。与ds -非hs患者相比，我们的数据报告了更高的BMI，并且与滤泡闭塞四分体有更大的关联。本研究的局限性包括其回顾性，样本量小，数据来自单一中心。结论：DS患儿HS发病早，BMI较高，以滤泡型为主，严重程度轻。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical and Experimental Dermatology 医学-皮肤病学

CiteScore

3.20

自引率

2.40%

发文量

389

审稿时长

3-8 weeks

期刊介绍： Clinical and Experimental Dermatology (CED) is a unique provider of relevant and educational material for practising clinicians and dermatological researchers. We support continuing professional development (CPD) of dermatology specialists to advance the understanding, management and treatment of skin disease in order to improve patient outcomes.