David A. Hoagey, Ekarin E. Pongpipat, Karen M. Rodrigue, Kristen M. Kennedy
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引用次数: 0
Abstract
A key aspect of brain aging that remains poorly understood is its high regional heterogeneity and heterochronicity. A better understanding of how the structural organization of the brain shapes aging trajectories is needed. Neuroimaging tissue “types” are often collected and analyzed as separate acquisitions, an approach that cannot provide a holistic view of age-related change in the related portions of the neurons (cell bodies and axons). Because neuroimaging can only assess indirect features at the gross macrostructural level, incorporating post-mortem histological information may aid in a better understanding of structural aging gradients. Longitudinal design, coupling of gray and white matter (GM and WM) properties, and a biologically informed approach to organizing neural properties are needed. Thus, we tested aging of the regional coupling between GM (cortical thickness, surface area, volume) and WM (fractional anisotropy, mean, axial, and radial diffusivities) structural metrics using linear mixed effects modeling in 102 healthy adults aged 20–94 years old, scanned on two occasions over a four-year period. The association between age-related within-person change in GM morphometry and the diffusion properties of the directly neighboring portion of white matter was assessed, capturing both aspects of neuronal health in one model. Additionally, we parcellated the brain utilizing the histological-staining informed von Economo-Koskinas atlas to consider regional cyto- and myelo-architecture. Results demonstrate several gradients of coupled association in the age-related decline of neighboring white and gray matter. Most notably, gradients of coupling along the heteromodal association to sensory axis were found for several areas (e.g., anterior frontal and lateral temporal cortices, vs. pre- and post-central gyrus, occipital, and limbic areas), in line with heterochronicity and retrogenesis theories of aging. Further effort to bridge across data and measurement scales will enhance understanding of the mechanisms of the aging brain.
期刊介绍:
Human Brain Mapping publishes peer-reviewed basic, clinical, technical, and theoretical research in the interdisciplinary and rapidly expanding field of human brain mapping. The journal features research derived from non-invasive brain imaging modalities used to explore the spatial and temporal organization of the neural systems supporting human behavior. Imaging modalities of interest include positron emission tomography, event-related potentials, electro-and magnetoencephalography, magnetic resonance imaging, and single-photon emission tomography. Brain mapping research in both normal and clinical populations is encouraged.
Article formats include Research Articles, Review Articles, Clinical Case Studies, and Technique, as well as Technological Developments, Theoretical Articles, and Synthetic Reviews. Technical advances, such as novel brain imaging methods, analyses for detecting or localizing neural activity, synergistic uses of multiple imaging modalities, and strategies for the design of behavioral paradigms and neural-systems modeling are of particular interest. The journal endorses the propagation of methodological standards and encourages database development in the field of human brain mapping.