Coupled Aging of Cyto- and Myeloarchitectonic Atlas-Informed Gray and White Matter Structural Properties

IF 3.5 2区 医学 Q1 NEUROIMAGING
David A. Hoagey, Ekarin E. Pongpipat, Karen M. Rodrigue, Kristen M. Kennedy
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Abstract

A key aspect of brain aging that remains poorly understood is its high regional heterogeneity and heterochronicity. A better understanding of how the structural organization of the brain shapes aging trajectories is needed. Neuroimaging tissue “types” are often collected and analyzed as separate acquisitions, an approach that cannot provide a holistic view of age-related change in the related portions of the neurons (cell bodies and axons). Because neuroimaging can only assess indirect features at the gross macrostructural level, incorporating post-mortem histological information may aid in a better understanding of structural aging gradients. Longitudinal design, coupling of gray and white matter (GM and WM) properties, and a biologically informed approach to organizing neural properties are needed. Thus, we tested aging of the regional coupling between GM (cortical thickness, surface area, volume) and WM (fractional anisotropy, mean, axial, and radial diffusivities) structural metrics using linear mixed effects modeling in 102 healthy adults aged 20–94 years old, scanned on two occasions over a four-year period. The association between age-related within-person change in GM morphometry and the diffusion properties of the directly neighboring portion of white matter was assessed, capturing both aspects of neuronal health in one model. Additionally, we parcellated the brain utilizing the histological-staining informed von Economo-Koskinas atlas to consider regional cyto- and myelo-architecture. Results demonstrate several gradients of coupled association in the age-related decline of neighboring white and gray matter. Most notably, gradients of coupling along the heteromodal association to sensory axis were found for several areas (e.g., anterior frontal and lateral temporal cortices, vs. pre- and post-central gyrus, occipital, and limbic areas), in line with heterochronicity and retrogenesis theories of aging. Further effort to bridge across data and measurement scales will enhance understanding of the mechanisms of the aging brain.

Abstract Image

细胞和骨髓结构图谱相关的灰质和白质结构特性的耦合衰老
大脑衰老的一个关键方面仍然知之甚少是其高度的区域异质性和异质性。我们需要更好地了解大脑的结构组织是如何塑造衰老轨迹的。神经成像组织“类型”通常作为单独的获取来收集和分析,这种方法无法提供神经元相关部分(细胞体和轴突)与年龄相关的变化的整体视图。由于神经影像学只能评估大体宏观结构水平的间接特征,因此结合死后组织学信息可能有助于更好地理解结构老化梯度。纵向设计,灰质和白质(GM和WM)特性的耦合,以及组织神经特性的生物学方法是必要的。因此,我们使用线性混合效应模型对102名年龄在20-94岁的健康成年人进行了为期四年的两次扫描,测试了GM(皮质厚度、表面积、体积)和WM(分数各向异性、平均扩散率、轴向扩散率和径向扩散率)结构指标之间的区域耦合老化。评估了与年龄相关的人体内GM形态变化与直接邻近白质部分的扩散特性之间的关系,在一个模型中捕获了神经元健康的两个方面。此外,我们利用组织染色告知von Economo-Koskinas图谱对大脑进行包裹,以考虑区域细胞和骨髓结构。结果表明,邻近的白质和灰质在年龄相关的衰退中有几个耦合关联的梯度。最值得注意的是,在几个区域(例如,额叶前部和外侧颞叶皮层,中央前和后回,枕叶和边缘区)发现了沿异模关联到感觉轴的耦合梯度,这与衰老的异时性和逆行性理论一致。进一步跨越数据和测量尺度的努力将加强对大脑衰老机制的理解。
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来源期刊
Human Brain Mapping
Human Brain Mapping 医学-核医学
CiteScore
8.30
自引率
6.20%
发文量
401
审稿时长
3-6 weeks
期刊介绍: Human Brain Mapping publishes peer-reviewed basic, clinical, technical, and theoretical research in the interdisciplinary and rapidly expanding field of human brain mapping. The journal features research derived from non-invasive brain imaging modalities used to explore the spatial and temporal organization of the neural systems supporting human behavior. Imaging modalities of interest include positron emission tomography, event-related potentials, electro-and magnetoencephalography, magnetic resonance imaging, and single-photon emission tomography. Brain mapping research in both normal and clinical populations is encouraged. Article formats include Research Articles, Review Articles, Clinical Case Studies, and Technique, as well as Technological Developments, Theoretical Articles, and Synthetic Reviews. Technical advances, such as novel brain imaging methods, analyses for detecting or localizing neural activity, synergistic uses of multiple imaging modalities, and strategies for the design of behavioral paradigms and neural-systems modeling are of particular interest. The journal endorses the propagation of methodological standards and encourages database development in the field of human brain mapping.
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