Viral non-SARS-CoV-2 etiology of community-acquired pneumonia (CAP) in Southeast Asia: a review and pooled analysis

IF 1.7 Q4 INFECTIOUS DISEASES

IJID regions Pub Date : 2025-06-01 DOI:10.1016/j.ijregi.2025.100672

Su Myat Han , Puah Ser Hon , Ho Ying Na , Trevor Tan Hwee Yong , Paul Anantharajah Tambyah , Yeo Tsin Wen

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Abstract

Community-acquired pneumonia (CAP) remains a leading cause of morbidity and mortality worldwide, including in Southeast Asia (SEA). While bacterial causes are well studied, viral etiologies are less characterized. The COVID-19 pandemic has underscored the significance of viral pneumonia, alongside ongoing concerns from zoonotic influenza, human metapneumovirus, and other outbreaks. This review identified 16 studies from SEA, encompassing 8421 CAP patients (2012-2023), describing the viral etiology of CAP. Influenza virus (IV), respiratory syncytial virus (RSV), and human rhinovirus/enterovirus (hRV/EV) were the most frequently tested viral pathogens in 16, 13, and 12 studies, respectively. The pooled positivity rates were 9.02% (hRV/EV), 7.28% (IV), and 5.17% (RSV). While viral etiologies of CAP in SEA align with global trends, data remain limited. Enhancing microbiology capacity in SEA is essential to strengthen CAP surveillance, optimize treatment strategies, inform vaccination policies, and improve pandemic preparedness.

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东南亚社区获得性肺炎（CAP）的病毒性非sars - cov -2病因学：综述和汇总分析

社区获得性肺炎（CAP）仍然是世界范围内发病和死亡的主要原因，包括东南亚（SEA）。虽然细菌病因研究得很好，但病毒病因的特征较少。2019冠状病毒病大流行凸显了病毒性肺炎的重要性，以及人畜共患流感、人偏肺病毒和其他疫情引发的持续担忧。本综述确定了来自SEA的16项研究，包括8421例CAP患者（2012-2023），描述了CAP的病毒病因学。流感病毒（IV）、呼吸道合胞病毒（RSV）和人鼻病毒/肠病毒（hRV/EV）分别是16、13和12项研究中最常检测的病毒病原体。合并阳性率分别为9.02% （hRV/EV）、7.28% （IV）和5.17% （RSV）。虽然东南亚地区CAP的病毒病因与全球趋势一致，但数据仍然有限。加强东南亚地区微生物学能力对于加强CAP监测、优化治疗战略、为疫苗接种政策提供信息以及改善大流行防范至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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