Antioxidant RuCo nanosheet attenuates capsule fibrosis in adhesive capsulitis of shoulder by p38 MAPK signaling pathway inhibition

IF 8.7 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio Pub Date : 2025-06-11 DOI:10.1016/j.mtbio.2025.101979

Beijie Qi , Zhixin Chen , Han Lin , Yaying Sun , Chengqing Yi , Jiwu Chen

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Abstract

Adhesive capsulitis of shoulder (ACS) is a prevalent orthopedic disorder characterized by pain and restricted range of motion (ROM). The pathogenesis of ACS remains unclear and current treatments have limited efficacy in terms of long-term outcomes. Here, we synthesized antioxidant RuCo nanosheets (RuCo-NSs) for the treatment of ACS. The reactive oxygen species (ROS) scavenging ability and the effect of RuCo-NSs on the activation of mouse fibroblasts NIH3T3s were investigated. In addition, RuCo-NSs were administered to the mouse model of ACS through intra-articular injection into joint capsule. Results showed that RuCo-NSs could effectively scavenge ROS in both the acellular and intracellular environments with low toxicity. Moreover, RuCo-NSs significantly suppressed the proliferation, migration and fibrogenesis of NIH3T3 via modulating the p38 mitogen-activated protein kinase (MAPK) signaling pathway. In addition, RuCo-NSs improved shoulder stiffness and inhibited capsular fibrosis in ACS mice. Our results suggest that the use of RuCo-NSs may be a potential therapy for ACS.

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抗氧化剂RuCo纳米片通过抑制p38 MAPK信号通路减轻肩粘连性囊炎的胶囊纤维化

肩关节粘连性囊炎（ACS）是一种常见的骨科疾病，其特征是疼痛和活动范围受限。ACS的发病机制尚不清楚，目前的治疗方法在长期预后方面疗效有限。在这里，我们合成了抗氧化剂RuCo纳米片（RuCo- nss）来治疗ACS。研究了RuCo-NSs对小鼠成纤维细胞nih3t3的活性氧（ROS）清除能力及对nih3t3活化的影响。此外，将RuCo-NSs通过关节囊内注射给药于小鼠ACS模型。结果表明，RuCo-NSs在细胞外和细胞内均能有效清除ROS，且毒性低。此外，RuCo-NSs通过调节p38丝裂原活化蛋白激酶（MAPK）信号通路显著抑制NIH3T3的增殖、迁移和纤维化。此外，RuCo-NSs可改善ACS小鼠的肩关节僵硬，抑制囊纤维化。我们的结果表明使用RuCo-NSs可能是ACS的一种潜在治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Materials Today Bio Multiple-

CiteScore

8.30

自引率

4.90%

发文量

303

审稿时长

30 days

期刊介绍： Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).