Batzelladine Q, a new guanidine alkaloid from the marine sponge Monanchora arbuscula

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-06-13 DOI:10.1016/j.phytol.2025.103005

Marcelo R. de Amorim , Anderson L. Noronha , Kamila L. Macedo , Karina F. Baracco , Caue A.W. Zuccarino , Tiago A. Paz , Antonio G. Ferreira , Tiago Venâncio , Eduardo Hajdu , Roberto G.S. Berlinck

引用次数: 0

Abstract

A chemical investigation of the organic-soluble extract obtained from the marine sponge Monanchora arbuscula, collected at the southeastern coastline of Brazil, led to the isolation of a new minor guanidine alkaloid, batzelladine Q (1), along with known alkaloids batzelladines L (2) and F (3), clathriadic acid (4), mirabilin B (5), ptilocaulin (6), netamine M (7) and the degraded carotenoid derivative 9-apoastaxanthinone (8). All compounds were identified by analysis of spectroscopic data. The absolute configurations of compounds 4 and 8 were for the first time established by the comparison of experimental ECD spectra with calculated CD data.

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Batzelladine Q：一种从海海绵中提取的新型胍类生物碱

从巴西东南海岸线采集的海海绵Monanchora arbuscula有机可溶性提取物中分离出一种新的次要胍类生物碱batzelladine Q(1)，以及已知的生物碱batzelladines L(2)和F (3)， clathriadic酸(4),mirabilin B (5), ptilocaulin (6), netamine M(7)和降解的类胡萝卜素衍生物9-apoastaxanthinone(8)。所有化合物均通过光谱分析得到。化合物4和8的绝对构型首次通过实验ECD光谱与计算CD数据的比较得到。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.