CF3-functionalized polyamide layers enhancing solvent permeability of polyimide-based organic solvent nanofiltration membranes for pharmaceutical separation

IF 6.7 2区工程技术 Q1 ENGINEERING, CHEMICAL

Journal of water process engineering Pub Date : 2025-06-13 DOI:10.1016/j.jwpe.2025.108139

Xiaolei Wang , Jingguo Zhang , Jing Feng , Shurui Han , Chan Huang , Zhiyun Kong , Huicai Wang

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Abstract

An organic solvent nanofiltration (OSN) membrane was fabricated through interfacial polymerization (IP) to form a selective layer containing hydrophilic amide (–CONH–) and hydrophobic trifluoromethyl (–CF₃) groups on a polyimide (PI) substrate. Piperazine (PIP) and 5-trifluoromethyl-1,3-phenylenediamine (TFMPD) were employed as aqueous phase monomers, reacting with trimesoyl chloride (TMC) in the organic phase. The effects of TFMPD incorporation on the chemical structure, morphology, surface properties, separation performance, and stability of the membranes were systematically investigated. The results revealed that the competitive reaction between TFMPD and PIP led to a thinner selective layer with reduced cross-linking degree, thereby enhancing solvent permeance while maintaining consistent pharmaceutical rejection. Specifically, the introduction of –CF₃ groups improved non-polar solvent transport, achieving a 3.2-fold increase in n-hexane permeance. After 91 days of immersion in N, N-dimethylformamide (DMF), the membrane retained ~94 % rifampicin (RFP) rejection and maintained an ethanol/water permeance of ~4.5 L·m⁻²·h⁻¹·bar⁻¹. This work demonstrates a rational design strategy for developing solvent-resistant OSN membranes with balanced permeability-selectivity-stability for pharmaceutical separation in organic solvents.

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cf3功能化聚酰胺层提高聚酰亚胺基有机溶剂纳滤膜药物分离的溶剂渗透性

通过界面聚合（IP）制备有机溶剂纳滤（OSN）膜，在聚酰亚胺（PI）衬底上形成含有亲水性酰胺（- conh -）和疏水性三氟甲基（- cf3）基团的选择层。以哌嗪（PIP）和5-三氟甲基-1,3-苯二胺（TFMPD）为水相单体，在有机相中与三甲基氯（TMC）反应。系统研究了TFMPD掺入对膜的化学结构、形貌、表面性能、分离性能和稳定性的影响。结果表明，TFMPD和PIP之间的竞争反应导致选择层更薄，交联度降低，从而增强溶剂渗透性，同时保持一致的药物排斥。具体来说，-CF3基团的引入改善了非极性溶剂的传输，使正己烷的渗透率提高了3.2倍。在N， N-二甲基甲酰胺（DMF）中浸泡91天后，膜保留了~ 94%的利福平（RFP）排除率，并保持了~4.5 L·m−2·h−1·bar−1的乙醇/水渗透率。这项工作证明了一种合理的设计策略，用于开发具有平衡的渗透性-选择性-稳定性的耐溶剂OSN膜，用于有机溶剂中的药物分离。

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来源期刊

Journal of water process engineering Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

10.70

自引率

8.60%

发文量

846

审稿时长

24 days

期刊介绍： The Journal of Water Process Engineering aims to publish refereed, high-quality research papers with significant novelty and impact in all areas of the engineering of water and wastewater processing . Papers on advanced and novel treatment processes and technologies are particularly welcome. The Journal considers papers in areas such as nanotechnology and biotechnology applications in water, novel oxidation and separation processes, membrane processes (except those for desalination) , catalytic processes for the removal of water contaminants, sustainable processes, water reuse and recycling, water use and wastewater minimization, integrated/hybrid technology, process modeling of water treatment and novel treatment processes. Submissions on the subject of adsorbents, including standard measurements of adsorption kinetics and equilibrium will only be considered if there is a genuine case for novelty and contribution, for example highly novel, sustainable adsorbents and their use: papers on activated carbon-type materials derived from natural matter, or surfactant-modified clays and related minerals, would not fulfil this criterion. The Journal particularly welcomes contributions involving environmentally, economically and socially sustainable technology for water treatment, including those which are energy-efficient, with minimal or no chemical consumption, and capable of water recycling and reuse that minimizes the direct disposal of wastewater to the aquatic environment. Papers that describe novel ideas for solving issues related to water quality and availability are also welcome, as are those that show the transfer of techniques from other disciplines. The Journal will consider papers dealing with processes for various water matrices including drinking water (except desalination), domestic, urban and industrial wastewaters, in addition to their residues. It is expected that the journal will be of particular relevance to chemical and process engineers working in the field. The Journal welcomes Full Text papers, Short Communications, State-of-the-Art Reviews and Letters to Editors and Case Studies