Water-Dispersible Glassy Organic Dots Exhibiting Near-Infrared Delayed Emission for Bioimaging

IF 5.3 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Nano Materials Pub Date : 2025-06-02 DOI:10.1021/acsanm.5c0104910.1021/acsanm.5c01049

Tinotenda R. Masvikeni, William L. Primrose, Sydney Mikulin and Zachary M. Hudson*,

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引用次数: 0

Abstract

Red to near-infrared (NIR) emitting thermally activated delayed fluorescence (TADF) emitters and room temperature phosphorescence (RTP) emitters are attractive for time-gated biological imaging. Luminophores that emit red to NIR light can operate within the biological transparency window (650–1350 nm), enabling deeper penetration into tissue while also being easier to distinguish from cellular autofluorescence. Herein, we report a TADF emitter NAI-Q-MeOTPA and an RTP emitter NAI-Py-MeOTPA which incorporate the strong electron-donating group bis(4-methoxyphenyl)amine and strong acceptor cores quinoxaline-naphthalimide and pyrido[2,3-b]pyrazine-naphthalimide, respectively. Delayed emission was observed for both luminophores with emission maxima for NAI-Q-MeOTPA and NAI-Py-MeOTPA of 746 and 749 nm in toluene, respectively. When encapsulated into glassy organic dots (g-Odots), the luminophores still maintained NIR emission with significant delayed lifetimes. The NAI-Q-MeOTPA and NAI-Py-MeOTPA g-Odots were probed for bioimaging in HeLa cells in which g-Odot uptake was observed and demonstrated bioimaging capability in the 630–740 nm imaging window.

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具有近红外延迟发射的水分散玻璃有机点用于生物成像

红到近红外（NIR）发射热激活延迟荧光（TADF）发射器和室温磷光（RTP）发射器是有吸引力的时间门控生物成像。发出红光到近红外光的发光团可以在生物透明窗口（650-1350 nm）内工作，能够更深地渗透到组织中，同时也更容易与细胞自身荧光区分开来。本文报道了一个含有强给电子基团双（4-甲氧基苯基）胺和强受体核心喹草啉-萘酰亚胺和吡啶[2,3-b]吡嗪-萘酰亚胺的TADF发射器NAI-Q-MeOTPA和RTP发射器NAI-Py-MeOTPA。在甲苯中，NAI-Q-MeOTPA和NAI-Py-MeOTPA的最大发射波长分别为746 nm和749 nm。当被封装成玻璃状有机点（g-Odots）时，发光团仍然保持近红外发射，并显着延迟寿命。NAI-Q-MeOTPA和NAI-Py-MeOTPA g-Odots在HeLa细胞中进行生物成像探测，观察到g-Odot摄取，并在630-740 nm成像窗口显示出生物成像能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Nano Materials Multiple-

CiteScore

8.30

自引率

3.40%

发文量

1601

期刊介绍： ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.