Controlled Regulation of Antibacterial and Degradable Performance via Host (Cyclodextrin)–Guest (Vanillin) Multilevel Structures

IF 5.1 Q1 POLYMER SCIENCE

ACS Macro Letters Pub Date : 2025-06-12 DOI:10.1021/acsmacrolett.5c00208

Jun Li, Xiaoqi Cheng, Rongmin Wang, Yaping Zhang, Yufeng He, Pengfei Song

{"title":"Controlled Regulation of Antibacterial and Degradable Performance via Host (Cyclodextrin)–Guest (Vanillin) Multilevel Structures","authors":"Jun Li, Xiaoqi Cheng, Rongmin Wang, Yaping Zhang, Yufeng He, Pengfei Song","doi":"10.1021/acsmacrolett.5c00208","DOIUrl":null,"url":null,"abstract":"The development of biobased polymeric materials is expected to reduce dependence on nonrenewable resources. However, the controlled regulation of performance via host–guest multilevel structures remains a great challenge. To tackle this challenge, host–guest block copolymers (P(CD)2-b-P(VMA)x, x = 7, 10, 72, 159) were fabricated by reversible addition–fragmentation chain transfer (RAFT) block copolymerization using β-cyclodextrin-derived monomer and biomass-derived vanillin monomer as the host–guest building blocks. In parallel, P(CD)2-b-P(VMA)x self-assembled in situ into honeycomb nanoporous channel materials via two-dimensional (2D) mechanical interlocking and three-dimensional (3D) physical cross-linking. Notably, high cross-linking density (x = 7, 10) showed 89.0% against both E. coli and S. aureus and complete hydrolysis of the ester bonds of host–guest building blocks on the copolymer chain, while low cross-linking density (x = 72, 159) had no antibacterial activity and was partially hydrolyzed. Overall, this strategy showcases an approach for regulating the multilevel structures, providing an eco-friendly material with adjustable properties.","PeriodicalId":18,"journal":{"name":"ACS Macro Letters","volume":"27 1","pages":""},"PeriodicalIF":5.1000,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Macro Letters","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1021/acsmacrolett.5c00208","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}

引用次数: 0

Abstract

The development of biobased polymeric materials is expected to reduce dependence on nonrenewable resources. However, the controlled regulation of performance via host–guest multilevel structures remains a great challenge. To tackle this challenge, host–guest block copolymers (P(CD)₂-b-P(VMA)_x, x = 7, 10, 72, 159) were fabricated by reversible addition–fragmentation chain transfer (RAFT) block copolymerization using β-cyclodextrin-derived monomer and biomass-derived vanillin monomer as the host–guest building blocks. In parallel, P(CD)₂-b-P(VMA)_x self-assembled in situ into honeycomb nanoporous channel materials via two-dimensional (2D) mechanical interlocking and three-dimensional (3D) physical cross-linking. Notably, high cross-linking density (x = 7, 10) showed 89.0% against both E. coli and S. aureus and complete hydrolysis of the ester bonds of host–guest building blocks on the copolymer chain, while low cross-linking density (x = 72, 159) had no antibacterial activity and was partially hydrolyzed. Overall, this strategy showcases an approach for regulating the multilevel structures, providing an eco-friendly material with adjustable properties.

Abstract Image

查看原文本刊更多论文

宿主（环糊精）-客体（香兰素）多层结构对抗菌降解性能的调控

生物基高分子材料的发展有望减少对不可再生资源的依赖。然而，通过主客多层结构对性能进行可控调节仍然是一个巨大的挑战。为了解决这一问题，以β-环糊精衍生单体和生物质衍生香兰素单体为主体，采用可逆加成-破碎链转移（RAFT）嵌段共聚法制备了主客体嵌段共聚物(P（CD)2-b-P(VMA)x, x = 7,10,72,159）。同时，P(CD)2-b-P(VMA)x通过二维（2D）机械联锁和三维（3D）物理交联在原位自组装成蜂窝纳米孔通道材料。值得注意的是，高交联密度（x = 7, 10）对大肠杆菌和金黄色葡萄球菌均有89.0%的抑制作用，并能完全水解共聚物链上主-客构建块的酯键，而低交联密度（x = 72, 159）没有抗菌活性，且被部分水解。总的来说，这一策略展示了一种调节多层结构的方法，提供了一种具有可调节性能的环保材料。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ACS Macro Letters 化学-

CiteScore

10.40

自引率

3.40%

发文量

209

审稿时长

1 months

期刊介绍： ACS Macro Letters publishes research in all areas of contemporary soft matter science in which macromolecules play a key role, including nanotechnology, self-assembly, supramolecular chemistry, biomaterials, energy generation and storage, and renewable/sustainable materials. Submissions to ACS Macro Letters should justify clearly the rapid disclosure of the key elements of the study. The scope of the journal includes high-impact research of broad interest in all areas of polymer science and engineering, including cross-disciplinary research that interfaces with polymer science. With the launch of ACS Macro Letters, all Communications that were formerly published in Macromolecules and Biomacromolecules will be published as Letters in ACS Macro Letters.