Better SIFI than sorry

IF 10.1 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Sara Osman
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引用次数: 0
总比后悔好
后生动物细胞对具有挑战性的环境因素(如温度、渗透和化学压力)保持协调的能力对发育弹性至关重要。为此,细胞利用分子途径发出应激反应信号。例如,有缺陷的蛋白质输入线粒体激活应激反应激酶HRI。反过来,HRI磷酸化翻译起始因子,以调节新蛋白质的合成。因此,HRI防止细胞质中容易聚集的蛋白质过载,并允许受影响的线粒体有时间恢复。另一方面,应激反应的不受控制的激活本身对细胞是有害的,因为所描述的细胞活动(如蛋白质合成)的停止在延长时可能引发细胞退化和死亡。因此,沉默因子,如E3泛素连接酶SIFI,已经进化到在应激反应产生有害影响之前终止应激反应。SIFI是如何通过检测一系列不同的细胞分子来感知压力,从而引发压力反应失活的,目前还不清楚。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nature Structural & Molecular Biology
Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS
CiteScore
22.00
自引率
1.80%
发文量
160
审稿时长
3-8 weeks
期刊介绍: Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.
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