A simple, sensitive and wide range electrochemical sensor for tinidazole detection in water, food and pharmaceutical samples

IF 5.5 3区材料科学 Q1 ELECTROCHEMISTRY

Electrochimica Acta Pub Date : 2025-06-12 DOI:10.1016/j.electacta.2025.146678

Arun Warrier , Pooja Das Manjulabhai , Dhanya Gangadharan , Jeethu Raveendran

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Abstract

An electroanalytical method has been developed for the detection of tinidazole (TNZ) based on electrochemical reduction with a simple and inexpensive self-made screen-printed electrode (SPE). The present study has optimized the analytical method regarding the technique and electrochemical parameters using Differential Pulse Voltammetry (DPV). The calibration curve was obtained with a linear range of 20 μM - 2.7 mM range, with a limit of detection (LOD) and limit of quantification (LOQ) of 0.024 μM and 0.08 μM, respectively. The developed sensor is highly selective with no interference in the presence of amoxicillin, ciprofloxacin, paracetamol, glucose, and uric acid. The study showed excellent results for the analysis of tinidazole in food, water, and other environmental samples which is proved by the excellent recovery of tinidazole in water, honey, milk, and other real samples. The sensor also possessed good repeatability and reproducibility which proved to be a valuable tool for the detection of tinidazole in environment samples and also its application in diagnostics.

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一种简便、灵敏、宽量程检测水、食品和药品中替硝唑的电化学传感器

建立了一种简单廉价的自制丝网印刷电极（SPE）电化学还原法检测替硝唑（TNZ）的电分析方法。本研究从技术和电化学参数两个方面对差分脉冲伏安法的分析方法进行了优化。校准曲线的线性范围为20 μM ~ 2.7 mM，检出限和定量限分别为0.024 μM和0.08 μM。该传感器具有高度选择性，在存在阿莫西林、环丙沙星、扑热息痛、葡萄糖和尿酸时无干扰。本研究对食品、水和其他环境样品中替硝唑的分析结果很好，对水、蜂蜜、牛奶和其他实际样品中替硝唑的回收率也很好。该传感器具有良好的重复性和再现性，为环境样品中替硝唑的检测和诊断提供了有价值的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Electrochimica Acta 工程技术-电化学

CiteScore

11.30

自引率

6.10%

发文量

1634

审稿时长

41 days

期刊介绍： Electrochimica Acta is an international journal. It is intended for the publication of both original work and reviews in the field of electrochemistry. Electrochemistry should be interpreted to mean any of the research fields covered by the Divisions of the International Society of Electrochemistry listed below, as well as emerging scientific domains covered by ISE New Topics Committee.