Gold‐catalyzed synthesis of substituted 4‐pentafluorosulfanyl‐1,3‐oxazoles

Abstract

We report the first synthesis of pentafluorosulfanylated oxazoles through a gold(I) catalyzed cyclization of SF5‐alkynes and nitriles. We describe 17 examples of 4‐SF5‐oxazoles with NMR yield ranging from 3% to 75%. While the isolation of the pure pentafluorosulfanylated oxazoles proved challenging, the fluorinated heterocycles could nonetheless be obtained in yields between 14 and 52%, opening the door for their use as a novel fluorine‐containing scaffold.