A Microfluidic Platform for studying Supercritical fluid crystallization and its Applications

IF 6.1 2区工程技术 Q1 BIOCHEMICAL RESEARCH METHODS

Lab on a Chip Pub Date : 2025-06-12 DOI:10.1039/d4lc01032a

Fatma Ercicek, Arnaud Erriguible, Olivier N'Guyen, Pascale Subra-Paternault, Christelle Harscoat-Schiavo, Samuel Marre

引用次数: 0

Abstract

We demonstrate in here the development and use of an on-chip crystallization microfluidic device combined with in situ analytical techniques for supercritical antisolvent crystallization. The setup facilitated real-time observation of crystallization events under pressure, giving critical insights to the time-dependent dynamics of the crystallization process. By integrating Raman spectroscopy for continuous monitoring, the system enabled precise control of local species concentrations during diffusion-driven crystallization. The microfluidic platform demonstrated effectiveness in rapid crystal screening and the identification of new co-crystals.

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超临界流体结晶研究微流控平台及其应用

我们在这里展示了一种片上结晶微流控装置的开发和使用，结合了超临界反溶剂结晶的原位分析技术。该装置有助于实时观察压力下的结晶事件，为结晶过程的时间依赖性动力学提供关键见解。通过集成拉曼光谱进行连续监测，该系统能够在扩散驱动结晶过程中精确控制局部物种浓度。微流控平台在快速筛选晶体和鉴定新的共晶方面显示出有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lab on a Chip 工程技术-化学综合

CiteScore

11.10

自引率

8.20%

发文量

434

审稿时长

2.6 months

期刊介绍： Lab on a Chip is the premiere journal that publishes cutting-edge research in the field of miniaturization. By their very nature, microfluidic/nanofluidic/miniaturized systems are at the intersection of disciplines, spanning fundamental research to high-end application, which is reflected by the broad readership of the journal. Lab on a Chip publishes two types of papers on original research: full-length research papers and communications. Papers should demonstrate innovations, which can come from technical advancements or applications addressing pressing needs in globally important areas. The journal also publishes Comments, Reviews, and Perspectives.