Lycium b arbarum's diabetes secrets: A comprehensive review of cellular, molecular, and epigenetic targets with immune modulation and microbiome influence.

IF 8.9
Journal of pharmaceutical analysis Pub Date : 2025-05-01 Epub Date: 2024-10-28 DOI:10.1016/j.jpha.2024.101130
Zeshan Ali, Aqsa Ayub, Yawen Lin, Sonam Anis, Ishrat Khan, Shoaib Younas, Rana Adnan Tahir, Shulin Wang, Jianrong Li
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Abstract

Diabetes, a metabolic disease stemming from impaired or defective insulin secretion, ranks among the most severe chronic illnesses globally. While several approved drugs exist for its treatment, they often come with multiple side effects. Therefore, there is a pressing need for safe and effective anti-diabetic medications. Traditional Chinese medicine has recognized Lycium barbarum (LB; goji berry) plant, commonly known as "wolfberry fruit" in China, for over 2,000 years. Natural compounds derived from LB show promise in reducing diabetes levels. Although research on the impact of LB on diabetes is still limited, our review aims to explore the potential of LB in reducing the risk of diabetes and examine the underlying mechanisms involved. LB can modulate diabetes through various pathways, such as inhibiting α-amylase and α-glucosidase activities, promoting β-cell proliferation, stimulating insulin secretion, inhibiting glucagon secretion, improving insulin resistance and glucose tolerance, and enhancing antioxidant and anti-inflammatory activities. Additionally, LB improves gut flora and immunomodulation, further aiding diabetes management. These findings highlight the potential clinical utility of LB in managing diabetes and its complications within the framework of evidence-based modern medicine.

枸杞糖尿病的秘密:细胞、分子和表观遗传靶标与免疫调节和微生物影响的综合综述。
糖尿病是一种由胰岛素分泌受损或缺陷引起的代谢性疾病,是全球最严重的慢性疾病之一。虽然有几种被批准的治疗这种疾病的药物,但它们往往有多种副作用。因此,迫切需要安全有效的抗糖尿病药物。中药公认枸杞(Lycium barbarum;枸杞)植物,在中国俗称“枸杞果”,已有2000多年的历史。从LB中提取的天然化合物显示出降低糖尿病水平的希望。虽然关于LB对糖尿病影响的研究仍然有限,但我们的综述旨在探讨LB在降低糖尿病风险方面的潜力,并研究其潜在机制。LB可通过抑制α-淀粉酶和α-葡萄糖苷酶活性,促进β-细胞增殖,刺激胰岛素分泌,抑制胰高血糖素分泌,改善胰岛素抵抗和糖耐量,增强抗氧化和抗炎活性等多种途径调节糖尿病。此外,LB改善肠道菌群和免疫调节,进一步帮助糖尿病管理。这些发现强调了LB在循证现代医学框架内管理糖尿病及其并发症的潜在临床应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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