C-reactive protein as a predictor of complicated acute cholecystitis: A cohort study

Revista de gastroenterologia de Mexico (English) Pub Date : 2025-04-01 DOI:10.1016/j.rgmxen.2025.02.004

G. Renau , D. Abelló , F. Sabench , J. Doménech , A. Sánchez

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引用次数: 0

Abstract

Introduction

The Tokyo Guidelines for the severity classification of acute cholecystitis (AC) include leukocytosis as a severity classifier, without considering C-reactive protein (CRP). Our aim was to determine which of the two variables has a greater predictive capacity for local complications in AC (LCAC).

Material and methods

A retrospective single-center study was conducted on patients that underwent emergency cholecystectomy within the time frame of June 2022 and December 2023. The variables associated with LCAC were analyzed and an ROC analysis was carried out.

Results

The multivariate analysis of 145 patients identified the following associations with LCAC: CRP (p < 0.001; OR 11.8), AUC of 0.88 (p = 0.029), and cutoff point of 4 mg/dl (88% sensitivity, 71% specificity); leukocytosis (p < 0.031; OR 5), AUC of 0.81(p = 0.037), and cutoff point of 11.09 x 10⁹/l (78% sensitivity, 70% specificity).

Conclusions

CRP may have a higher predictive capacity for LCAC than leukocytosis.

查看原文本刊更多论文

c反应蛋白作为复杂急性胆囊炎的预测因子：一项队列研究。

导论：东京急性胆囊炎（AC）严重程度分级指南包括白细胞增多作为严重程度分级，没有考虑c反应蛋白（CRP）。我们的目的是确定这两个变量中哪一个对AC （LCAC）的局部并发症有更大的预测能力。材料和方法：对2022年6月至2023年12月期间行急诊胆囊切除术的患者进行回顾性单中心研究。分析与LCAC相关的变量，并进行ROC分析。结果：145例患者的多因素分析确定了以下与LCAC的相关性：CRP (p 9/l（78%敏感性，70%特异性）。结论：CRP对LCAC的预测能力可能高于白细胞计数。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista de gastroenterologia de Mexico (English)

自引率

0.00%

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审稿时长

12 weeks