Alessandra Gentile, Katerina Stavropoulou, Katherine R Long
{"title":"ECM Mechanics in Central Nervous System Morphogenesis.","authors":"Alessandra Gentile, Katerina Stavropoulou, Katherine R Long","doi":"10.1159/000546414","DOIUrl":null,"url":null,"abstract":"<p><p>Morphogenesis is crucial to shape tissues and embryos during development and results from a combination of gene expression, extracellular matrix (ECM) remodelling and mechanical forces. The roles of gene regulation, biochemical signalling and cell-generated forces have been extensively studied, but little is known about the active role of the ECM and the contribution of extracellular forces in shaping tissues. This is especially true for the central nervous system (CNS) and the neural tissues it contains. It has been shown that ECM can have a direct and instructive role during CNS morphogenesis, but how the mechanical properties of the ECM and its regulation by these extracellular forces influence the shape of developing tissues is not yet fully understood. In this review, we will focus on the recent growing evidence of the direct role of the ECM and mechanics in the morphogenesis of the CNS.</p>","PeriodicalId":50585,"journal":{"name":"Developmental Neuroscience","volume":" ","pages":"1-16"},"PeriodicalIF":2.3000,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Developmental Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000546414","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Morphogenesis is crucial to shape tissues and embryos during development and results from a combination of gene expression, extracellular matrix (ECM) remodelling and mechanical forces. The roles of gene regulation, biochemical signalling and cell-generated forces have been extensively studied, but little is known about the active role of the ECM and the contribution of extracellular forces in shaping tissues. This is especially true for the central nervous system (CNS) and the neural tissues it contains. It has been shown that ECM can have a direct and instructive role during CNS morphogenesis, but how the mechanical properties of the ECM and its regulation by these extracellular forces influence the shape of developing tissues is not yet fully understood. In this review, we will focus on the recent growing evidence of the direct role of the ECM and mechanics in the morphogenesis of the CNS.
期刊介绍：
''Developmental Neuroscience'' is a multidisciplinary journal publishing papers covering all stages of invertebrate, vertebrate and human brain development. Emphasis is placed on publishing fundamental as well as translational studies that contribute to our understanding of mechanisms of normal development as well as genetic and environmental causes of abnormal brain development. The journal thus provides valuable information for both physicians and biologists. To meet the rapidly expanding information needs of its readers, the journal combines original papers that report on progress and advances in developmental neuroscience with concise mini-reviews that provide a timely overview of key topics, new insights and ongoing controversies. The editorial standards of ''Developmental Neuroscience'' are high. We are committed to publishing only high quality, complete papers that make significant contributions to the field.
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