Mandibular Advancement Devices for Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis.

IF 1.1 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

European Journal of Prosthodontics and Restorative Dentistry Pub Date : 2025-05-13 DOI:10.1922/EJPRD_2847Gunel09

E Günel, H M Kurtulmus, H Boyacioglu, M Özcan, V Colombo

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引用次数: 0

Abstract

Background: This systematic review and meta-analysis aimed to evaluate the effectiveness of mandibular advancement devices (MADs) in treating Obstructive Sleep Apnea (OSA), focusing on the impact of age and body mass index (BMI) on the apnea-hypopnea index (AHI) and minimum oxygen saturation (min SpO2).

Methods: A literature search was conducted in PubMed and Google Scholar for studies published from January 2013 to January 2023. Two independent authors screened the studies, assessed and evaluated risk of bias. Disagreements were resolved by consensus or consultation with a third reviewer and senior experts. The initial search yielded 1110 references, with 13 selected for inclusion.

Results: MADs significantly reduced AHI and increased min SpO2 in OSA patients. The mean difference in AHI was 15.75 (95% CI 13.19-18.30, p ⟨0.00001). Minimum SpO2 improved post-treatment (-3.70, 95% CI-5.52 to-1.88, p ⟨ 0.00001, Z = 3.98).

Conclusion: This meta-analysis demonstrated that MADs effectively reduced AHI severity and increased min SpO2 in OSA patients. While BMI had no significant effect, age had a notable impact on treatment outcomes.

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下颌推进装置治疗阻塞性睡眠呼吸暂停：系统回顾和荟萃分析。

背景：本系统综述和荟萃分析旨在评估下颌推进装置（MADs）治疗阻塞性睡眠呼吸暂停（OSA）的有效性，重点研究年龄和体重指数（BMI）对呼吸暂停低通气指数（AHI）和最低血氧饱和度（min SpO2）的影响。方法：在PubMed和谷歌Scholar中检索2013年1月至2023年1月发表的文献。两位独立作者筛选研究，评估和评估偏倚风险。分歧通过协商一致或与第三审稿人和资深专家协商解决。最初的搜索产生了1110个参考文献，其中13个被选中纳入。结果：MADs可显著降低OSA患者的AHI，增加最小SpO2。AHI的平均差异为15.75 （95% CI 13.19-18.30, p⟨0.00001）。最低SpO2改善后处理（-3.70,95% CI-5.52至1.88,p⟨0.00001,Z = 3.98）。结论：本荟萃分析表明，MADs可有效降低OSA患者的AHI严重程度并增加最小SpO2。虽然BMI没有显著影响，但年龄对治疗结果有显著影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Prosthodontics and Restorative Dentistry DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

2.30

自引率

7.70%

发文量

期刊介绍： The European Journal of Prosthodontics and Restorative Dentistry is published quarterly and includes clinical and research articles in subjects such as prosthodontics, operative dentistry, implantology, endodontics, periodontics and dental materials.