Control of aflatoxin in broiler feeds through dietary supplementation with Pichia kudriavzevii B-5P: effects on performance, serum biochemistry and histopathological change - a promosing strategy.

IF 4.2 3区 生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Lili Anggraini, Yetti Marlida, Harnentis, Yuliaty Shafan Nur, Laily Rinda Ardani
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Abstract

Aflatoxin is a mycotoxin that contaminates many grain feed ingredients, especially corn. Pichia kudriavzevii B-5P is a yeast strain with potential application in the mitigation of Aspergillus flavus and its associated aflatoxins. This research aims to optimize the dose of Pichia kudriavzevii B-5P as a toxin binder in corn containing aflatoxin in broiler chicken rations along with in vivo evaluation of its protection efficiency on performance, carcass characteristics, serum biochemistry and histopatholical alteration in the liver, kidneys and intestines. This research used a Completely Randomized Design (CRD), 4 treatments and 5 replications. Treatment consisted of T1: control (no aflatoxin); T2: 0,1% P. kudriavzevii B-5P; T3: 0,2% P. kudriavzevii B-5P; T4: 0,3% P. kudriavzevii B-5P. Performance (consumption, weight gain, feed conversion, live weight, and carcass), abdominal fat, percentage of organ weight (liver, kidney, and small intestine), and total protein, albumin, and globulin were not significantly different (p > 0.05) between the control group (without aflatoxin) and the group of chickens fed aflatoxin (191.95 ppb) + Pichia kudriavzevii B-5P. Histopathologically, the liver, kidneys, and small intestine showed mild damage that tended to improve with the administration of P. kudriavzevii B-5P, thereby not affecting organ function. The results of the study concluded that giving Pichia kudriavzevii B-5P as much as 0.1% in feed can overcome aflatoxin contamination with a level of 191.95 ppb in broiler chickens.

饲粮中添加毕赤酵母B-5P控制肉仔鸡黄曲霉毒素:对生产性能、血清生化和组织病理变化的影响
黄曲霉毒素是一种霉菌毒素,污染了许多谷物饲料原料,尤其是玉米。kudriavzevii毕赤酵母B-5P是一种具有抑制黄曲霉及其相关黄曲霉毒素潜力的酵母菌株。本研究旨在优化库氏毕赤酵母B-5P作为肉仔鸡饲料中含黄曲霉毒素玉米的毒素结合剂的剂量,并在体内评价其对肉鸡生产性能、胴体特性、血清生化和肝、肾、肠组织病理学改变的保护效果。本研究采用完全随机设计(CRD), 4个处理,5个重复。治疗包括T1:对照组(不含黄曲霉毒素);T2: 0.1% P. kudriavzevii B-5P;T3: 0.2% P. kudriavzevii B-5P;T4: 0.3% P. kudriavzevii B-5P。对照组(不含黄曲霉毒素)与黄曲霉毒素(191.95 ppb) +毕赤酵母B-5P组的生产性能(耗食量、增重、饲料转化率、活重、胴体)、腹脂、脏器重量(肝、肾、小肠)百分比、总蛋白、白蛋白和球蛋白均无显著差异(p < 0.05)。在组织病理学上,肝脏、肾脏和小肠表现出轻度损伤,随着P. kudriavzevii B-5P的施用,这些损伤趋于改善,因此不影响器官功能。研究结果表明,在饲料中添加0.1%的毕赤酵母B-5P可以克服肉鸡体内191.95 ppb的黄曲霉毒素污染。
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来源期刊
World journal of microbiology & biotechnology
World journal of microbiology & biotechnology 工程技术-生物工程与应用微生物
CiteScore
6.30
自引率
2.40%
发文量
257
审稿时长
2.5 months
期刊介绍: World Journal of Microbiology and Biotechnology publishes research papers and review articles on all aspects of Microbiology and Microbial Biotechnology. Since its foundation, the Journal has provided a forum for research work directed toward finding microbiological and biotechnological solutions to global problems. As many of these problems, including crop productivity, public health and waste management, have major impacts in the developing world, the Journal especially reports on advances for and from developing regions. Some topics are not within the scope of the Journal. Please do not submit your manuscript if it falls into one of the following categories: · Virology · Simple isolation of microbes from local sources · Simple descriptions of an environment or reports on a procedure · Veterinary, agricultural and clinical topics in which the main focus is not on a microorganism · Data reporting on host response to microbes · Optimization of a procedure · Description of the biological effects of not fully identified compounds or undefined extracts of natural origin · Data on not fully purified enzymes or procedures in which they are applied All articles published in the Journal are independently refereed.
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