Extraction, purification, structural characterisation, and anti-glycolipid metabolism disorder activities of Alpinia officinarum Hance polysaccharide.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-06-10 DOI:10.1080/14786419.2025.2509884

Wenzhao Wang, Qiuyun Li, Xinyu Chen, Jiayue Liang, Yiyang He, Yaowen Xing, Xubin Quan, Ningxin Yu, Peng Guo, Yanli Wu

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Abstract

Alpinia officinarum Hance is a traditional medicinal and edible plant, but research on its polysaccharides has been limited. In this study, a purified polysaccharide, named AOP-1-1, was successfully extracted. Its structure was meticulously analysed through techniques, such as NMR and HPLC. AOP-1-1 was determined to be an acidic heteropolysaccharide with high purity and uniformity. To further explore its potential medicinal value, its activity against glycolipid metabolism disorders was investigated. The results showed that AOP-1-1 could inhibit key enzymes involved in glucose metabolism and improve the abnormal levels of total cholesterol (TC) and triglycerides (TG) in oleic acid-induced HepG2 cells. Additionally, it demonstrated significant antioxidant activity. These findings provide a theoretical foundation for the further development and utilisation of A. officinarum Hance, opening up new possibilities for its application in the fields of medicine and health.

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高寒多糖的提取、纯化、结构表征及抗糖脂代谢紊乱活性研究。

高寒是一种传统的药用和食用植物，但对其多糖的研究一直很有限。本研究成功提取了一种纯化的多糖，命名为AOP-1-1。通过核磁共振和高效液相色谱等技术对其结构进行了细致的分析。AOP-1-1是一种纯度高、均匀性好的酸性杂多糖。为了进一步挖掘其潜在的药用价值，研究了其抗糖脂代谢紊乱的活性。结果表明，AOP-1-1能抑制油酸诱导的HepG2细胞中参与葡萄糖代谢的关键酶，改善总胆固醇（TC）和甘油三酯（TG）的异常水平。此外，它还具有显著的抗氧化活性。这些研究结果为其进一步开发利用提供了理论基础，为其在医药保健领域的应用开辟了新的可能性。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.