Cryopreservation and transplantation of ovarian tissue as post-cancer tissue therapy and an activator of oogenesis.

IF 4.2 3区医学 Q1 REPRODUCTIVE BIOLOGY

Journal of Ovarian Research Pub Date : 2025-06-10 DOI:10.1186/s13048-025-01680-9

Volodimir Isachenko, Bernd Morgenstern, Plamen Todorov, Evgenia Isachenko, Frank Nawroth, Maria Quassdorff, Mahmoud Salama, Nina Mallmann-Gottschalk, Markus Merzenich, Christine Skala, Gohar Rahimi

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引用次数: 0

Abstract

In a recent publication (Reprod. Biomed. Online, 2024) it was presented point of view that, for post-cancer patients, in vitro fertilization (IVF) is a more effective method than ovarian tissue cryopreservation (OTC). In their commentary, Andersen et al. (Reprod. Biomed. Online, 2024) present nine distinct arguments advocating for the use of OTC. We fully agree with all these points. In support of the clinical application of the OTC procedure, we introduce two additional arguments. First, the transplantation of cryopreserved ovarian tissue can be considered as a form of tissue therapy. Moreover, OTC inherently serves as an activator of oogenesis. Second, during tissue dissection prior to OTC, a significant number of germinal vesicle (GV) oocytes can be retrieved, matured to the metaphase II (MII) stage, cryopreserved, and later used in IVF procedures.

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冷冻保存和移植卵巢组织作为癌后组织治疗和卵子发生的激活剂。

在最近的一份出版物（转载）中。生物医学。Online, 2024)有人提出，对于癌症后患者，体外受精（IVF）是一种比卵巢组织冷冻保存（OTC）更有效的方法。在他们的评论中，Andersen等人。生物医学。在线，2024)提出了九个不同的论点，主张使用OTC。我们完全同意所有这些观点。为了支持OTC程序的临床应用，我们引入两个额外的论据。首先，冷冻卵巢组织移植可以被认为是组织治疗的一种形式。此外，OTC本身就是卵子生成的激活剂。其次，在OTC前的组织剥离过程中，可以回收大量的生发囊泡（GV）卵母细胞，成熟到中期II期（MII），冷冻保存，然后用于IVF手术。

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来源期刊

Journal of Ovarian Research REPRODUCTIVE BIOLOGY-

CiteScore

6.20

自引率

2.50%

发文量

125

审稿时长

>12 weeks

期刊介绍： Journal of Ovarian Research is an open access, peer reviewed, online journal that aims to provide a forum for high-quality basic and clinical research on ovarian function, abnormalities, and cancer. The journal focuses on research that provides new insights into ovarian functions as well as prevention and treatment of diseases afflicting the organ. Topical areas include, but are not restricted to: Ovary development, hormone secretion and regulation Follicle growth and ovulation Infertility and Polycystic ovarian syndrome Regulation of pituitary and other biological functions by ovarian hormones Ovarian cancer, its prevention, diagnosis and treatment Drug development and screening Role of stem cells in ovary development and function.