Lingna Fang, Zhiqin Zhang, Dawei He, Yanming Hao, Yan Gao, Rongzhu Lu, Chong Li
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引用次数: 0
Abstract
Background: The aim of this study was to examine the impact of a sulfur-containing diet and a CTH polymorphism (G1208T; rs1021737) on bone density.
Methods: A total of 200 Uyghur residents aged over 50 from Xinjiang, China, were recruited for this study. Fasting blood samples were collected from the participants to measure serum hydrogen sulfide (H2S) levels and perform CTH polymorphism sequencing. Dietary sulfur intake was assessed using a food frequency questionnaire and categorized into animal protein-derived and non-animal protein-derived sources. Skeletal health of the calcaneus was evaluated using quantitative ultrasound scanning.
Results: The study included a total of 200 participants, comprising 81 males and 119 females. Participants were stratified based on osteopenia status, with a T-score ≥ -1.0 indicating normal bone density and a T-score < -1.0 indicating osteopenia. Individuals in the osteopenia group exhibited significantly lower bone density markers, including broadband ultrasound attenuation (BUA) and speed of sound (SOS), as well as lower total weekly dietary sulfur intake and weekly dietary sulfur intake from animal protein. Additionally, they had significantly higher serum H2S levels compared to participants with normal bone density. However, no differences in CTH genotype were observed between the normal bone density group and the osteopenia group. Participants were further categorized into tertiles (Q1 to Q3) based on weekly dietary sulfur intake from animal protein. Compared to the Q1 group, the Q3 group showed significantly higher T-scores and BUA values. Binary logistic regression analysis revealed that, compared to the group with high weekly dietary sulfur intake from animal protein, the low and middle intake groups had 3.252 times and 4.330 times higher risks of osteopenia, respectively.
Conclusion: Dietary sulfur intake from animal protein may exert a protective effect on bone density.
期刊介绍：
The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas.
A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal.
As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.
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