Samuel Montenegro Pereira, Maria Alix Leite Araújo, Rian Vilar Lima, Rivianny Arrais Nobre, Ana Patrícia Alves da Silva, Ana Fátima Braga Rocha, Rodrigo Jorge, Nathalie Broutet
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引用次数: 0
Abstract
Purpose: Congenital syphilis (CS) is associated with interstitial keratitis, chorioretinitis, uveitis, and optic atrophy mainly in inadequately treated patients. We conducted a retrospective cohort analysis evaluating ocular findings in children born in 2015 with CS treated with ceftriaxone at the time of delivery during the period of penicillin shortage in a city located at Northeast of Brazil and compared them with those adequately treated.
Methods: 469 children were reported with CS at birth during the penicillin shortage period and 171 were actively searched and invited to an ophthalmological assessment and retrospective analysis of their information recorded in the medical records of the municipality's health services.
Results: A total of 68 children came to the assessment, median age 8 years of age (range 7-8 years), 48 were treated with penicillin (70.5%) and 20 with ceftriaxone (29.5%). There were no significant differences in demographic or perinatal characteristics between the groups. The majority of children had a completely normal ophthalmological examination (67.6%). Regarding findings that are more associated with CS, one child in ceftriaxone group (5.0%) had optic atrophy in one eye and one in the penicillin group (2.9%) had glaucomatous optic disc changes. No interstitial keratitis was found. There was no significant association between the child's treatment and the prevalence of ophthalmologic findings (p = 0.663). There was also no association between the medication and a current reactive VDRL (p = 1.000).
Conclusion: After an 8-year follow-up, no statistically significant difference was observed in the incidence of ophthalmologic manifestations among individuals treated for CS with either penicillin or ceftriaxone. These findings suggest that ceftriaxone may serve as an effective alternative for the prevention of CS and its associated ocular complications.
期刊介绍：
International Journal of Retina and Vitreous focuses on the ophthalmic subspecialty of vitreoretinal disorders. The journal presents original articles on new approaches to diagnosis, outcomes of clinical trials, innovations in pharmacological therapy and surgical techniques, as well as basic science advances that impact clinical practice. Topical areas include, but are not limited to: -Imaging of the retina, choroid and vitreous -Innovations in optical coherence tomography (OCT) -Small-gauge vitrectomy, retinal detachment, chromovitrectomy -Electroretinography (ERG), microperimetry, other functional tests -Intraocular tumors -Retinal pharmacotherapy & drug delivery -Diabetic retinopathy & other vascular diseases -Age-related macular degeneration (AMD) & other macular entities
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