Ying Gao, Jie Li, Fangxia Li, Ran Jia, Shuai Liu, Mingyu Wang, Na Tian, Wendi Wei, Linlin Kuang, Ruiliang Zhu, Xiaozhen Liang
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引用次数: 0
Abstract
The regulation of terminal differentiation of B cells into plasma cells is influenced by transcription factors, epigenetics, and cytokines. Both human and murine B cells possess the capacity to produce interleukin 16 (IL16), a pleiotropic cytokine that serves as a chemoattractant. Despite its production, the precise role of IL16 in B cells has remained elusive. In this study, we showed that IL16 overexpression promoted primary B cell differentiation into B220lowCD138+ plasma cells. This effect was independent of the secreted form of IL16. The overexpression of IL16 resulted in an increase in the expression of plasma transcription factors Blimp-1, IRF4, and Xbp-1, as well as the expression of immunoglobulin genes. Consistently, upon the inoculation of mice with influenza A virus, the absence of IL16 led to a decrease in the number of plasma cells and the production of virus-specific antibodies. Our data demonstrate that IL16 contributes to the terminal differentiation of B cells to plasma cells.
期刊介绍：
Immunology is one of the longest-established immunology journals and is recognised as one of the leading journals in its field. We have global representation in authors, editors and reviewers.
Immunology publishes papers describing original findings in all areas of cellular and molecular immunology. High-quality original articles describing mechanistic insights into fundamental aspects of the immune system are welcome. Topics of interest to the journal include: immune cell development, cancer immunology, systems immunology/omics and informatics, inflammation, immunometabolism, immunology of infection, microbiota and immunity, mucosal immunology, and neuroimmunology.
The journal also publishes commissioned review articles on subjects of topical interest to immunologists, and commissions in-depth review series: themed sets of review articles which take a 360° view of select topics at the heart of immunological research.
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