Cell death: Dynamics and compartmentalization of NADH and FSP1 in ferroptosis.

IF 8.1 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current Biology Pub Date : 2025-06-09 DOI:10.1016/j.cub.2025.04.012

Amalia H Megarioti, Kirandeep K Deol, James A Olzmann

引用次数: 0

Abstract

A new study identifies the aldehyde dehydrogenase ALDH7A1 as a key regulator of ferroptosis. ALDH7A1 generates a pool of membrane-associated NADH, which is used by ferroptosis suppressor protein 1 to recycle the lipid antioxidant coenzyme Q₁₀ and suppress ferroptosis.

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细胞死亡：铁下垂中NADH和FSP1的动态和区隔化。

一项新的研究发现醛脱氢酶ALDH7A1是铁下垂的关键调节因子。ALDH7A1产生一池膜相关NADH，由铁下垂抑制蛋白1回收脂质抗氧化辅酶Q10，抑制铁下垂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Biology 生物-生化与分子生物学

CiteScore

11.80

自引率

2.20%

发文量

869

审稿时长

46 days

期刊介绍： Current Biology is a comprehensive journal that showcases original research in various disciplines of biology. It provides a platform for scientists to disseminate their groundbreaking findings and promotes interdisciplinary communication. The journal publishes articles of general interest, encompassing diverse fields of biology. Moreover, it offers accessible editorial pieces that are specifically designed to enlighten non-specialist readers.