Does Syphilis need to be Examined in Cases of Blood and Body Fluid Exposure in Hospitals?

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Clinical laboratory Pub Date : 2025-06-01 DOI:10.7754/Clin.Lab.2024.241142

Hideharu Hagiya

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引用次数: 0

Abstract

Background: Syphilis, caused by Treponema pallidum, represents a significant sexually transmitted infection capable of systemic manifestation. Current guidelines do not recommend syphilis serological screening following blood and body fluid exposure (BBFE) in healthcare settings. This cross-sectional study examined current practices of rapid plasma reagin (RPR) and T. pallidum hemagglutination (TPHA) testing in Japanese hospitals.

Methods: A web-based questionnaire distributed in November 2023 assessed institutional testing policies and post-exposure protocols.

Results: Among 23 responding institutions, preoperative screening included both RPR and TPHA in nine hospitals (39%) and TPHA alone in seven (31%). For non-preoperative screening, five hospitals (22%) conducted both tests, while six (26%) performed TPHA only. No consensus existed regarding test validity duration, and only one hospital maintained post-exposure prophylaxis protocols.

Conclusions: Although approximately 75% of institutions conduct routine preoperative syphilis screening, the lack of evidence supporting BBFE transmission and prophylaxis necessitates practice reconsideration.

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医院血液和体液接触病例是否需要检查梅毒？

背景：梅毒是由梅毒螺旋体引起的一种重要的性传播感染，具有全身表现。目前的指南不建议在卫生保健机构进行血液和体液暴露（BBFE）后进行梅毒血清学筛查。本横断面研究检查了日本医院快速血浆反应素（RPR）和T. pallidum血凝素（TPHA）检测的现行做法。方法：于2023年11月发放一份基于网络的问卷，评估机构检测政策和暴露后协议。结果：在23家应答机构中，术前筛查包括RPR和TPHA的医院有9家（39%），单独筛查TPHA的医院有7家（31%）。对于非术前筛查，五家医院（22%）同时进行两种检测，而六家医院（26%）仅进行TPHA检测。关于测试的有效期限没有达成共识，只有一家医院维持接触后预防方案。结论：虽然大约75%的机构进行常规术前梅毒筛查，但缺乏支持BBFE传播和预防的证据，需要重新考虑实践。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.