Cardiac Magnetic Resonance Imaging Markers in Idiopathic Inflammatory Myopathy - A Prospective Observational Study.

IF 1.9 4区医学 Q3 CLINICAL NEUROLOGY

Annals of Indian Academy of Neurology Pub Date : 2025-05-01 Epub Date: 2025-06-11 DOI:10.4103/aian.aian_1001_24

M M Samim, Ashita Barthur, Seena Vengalil, Saraswati Nashi, Deepak Menon, Kartik Ganga, Bhavana Krishna Gutta, Abhijeet Narsing Jadhao, Dipti Baskar, Ravindu Tiwari, S G Manu, Vidya Nittur, Priya Treesa Thomas, Talakad N Sathyaprabha, Atchayaram Nalini

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引用次数: 0

Abstract

Background and objectives: Idiopathic inflammatory myopathies (IIMs) encompass a spectrum of conditions with diverse muscular and extra-muscular symptoms, including cardiac manifestations, which significantly impact morbidity and mortality. Our study aims to assess cardiac involvement markers in IIM using cardiac magnetic resonance imaging (CMR) and evaluate their association with disease severity.

Methods: We recruited 62 participants prospectively, including 31 clinically suspected IIM patients and 31 healthy controls who were matched by age and sex. CMR with multiparametric mapping (1.5 T magnetic resonance imaging) and the Myositis Disease Activity Assessment Tool (MDAAT) were used in the evaluation.

Results: With a mean age of 35.3 ± 12.2 years and a female preponderance (F:M = 2.4:1), the majority of the study population (77.4%) exhibited positive myositis-specific antibodies, whereas 45.2% had myositis-associated antibodies. Cardiac symptoms were reported by 45.2% of the cases, while 48.3% had an MDAAT cardiac Visual Analog Scale (VAS) score of ≥1, indicating potential cardiac involvement. Cases had significantly higher native T1 and T2 mapping values (1085.7 ± 57.7 vs. 1043.3 ± 36.1 ms, P = 0.002 and 52.9 ± 4.3 vs. 50.4 ± 2.6 ms, P = 0.011, respectively). Late gadolinium enhancement was seen in 6.4%. The native T1 value positively correlated with the MDAAT total score (ρ = 0.376, P < 0.014) and cardiac VAS score (ρ = 0.259, P = 0.038). A native T1 value ≥1048.25 ms has 72.7% sensitivity and 51.4% specificity (AUC = 0.711, P = 0.019) in detecting cardiac involvement.

Conclusions: Clinical parameters and CMR multiparametric mapping are shown to be correlated in this prospective investigation. It is the first study to look at the cardiac mapping parameters' sensitivity and specificity to MDAAT-based cardiac involvement. In the Indian population with IIM, it is the first assessment of cardiac involvement utilizing CMR. In IIM, this endeavor is expected to greatly improve early detection, prevention, and treatment of cardiac complications.

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特发性炎性肌病的心脏磁共振成像标志物-一项前瞻性观察研究。

背景和目的：特发性炎症性肌病（IIMs）包括一系列具有不同肌肉和肌肉外症状的疾病，包括心脏表现，这些症状显著影响发病率和死亡率。本研究旨在利用心脏磁共振成像（CMR）评估IIM的心脏受累标志物，并评估其与疾病严重程度的关系。方法：我们前瞻性地招募了62名参与者，包括31名临床疑似IIM患者和31名年龄和性别匹配的健康对照。采用CMR多参数定位（1.5 T磁共振成像）和肌炎疾病活动评估工具（MDAAT）进行评估。结果：平均年龄为35.3±12.2岁，女性居多（F:M = 2.4:1），大多数研究人群（77.4%）表现出肌炎特异性抗体阳性，而45.2%表现出肌炎相关抗体。45.2%的病例报告有心脏症状，48.3%的病例MDAAT心脏视觉模拟评分（VAS）评分≥1，表明可能有心脏受累。患者的T1、T2定位值明显高于患者（1085.7±57.7 vs 1043.3±36.1 ms, P = 0.002; 52.9±4.3 vs 50.4±2.6 ms, P = 0.011）。晚期钆强化占6.4%。原生T1值与MDAAT总分（ρ = 0.376, P < 0.014）、心脏VAS评分（ρ = 0.259, P = 0.038）呈正相关。原生T1值≥1048.25 ms检测心脏受累的敏感性为72.7%，特异性为51.4% （AUC = 0.711, P = 0.019）。结论：在这项前瞻性研究中，临床参数和CMR多参数定位显示出相关性。这是第一个研究心脏定位参数对mdaat心脏受累的敏感性和特异性的研究。在印度IIM患者中，这是首次使用CMR评估心脏受累情况。在IIM中，这一努力有望大大改善心脏并发症的早期发现、预防和治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Indian Academy of Neurology Nervous System Diseases-

CiteScore

2.20

自引率

11.80%

发文量

293

审稿时长

29 weeks

期刊介绍： The journal has a clinical foundation and has been utilized most by clinical neurologists for improving the practice of neurology. While the focus is on neurology in India, the journal publishes manuscripts of high value from all parts of the world. Journal publishes reviews of various types, original articles, short communications, interesting images and case reports. The journal respects the scientific submission of its authors and believes in following an expeditious double-blind peer review process and endeavors to complete the review process within scheduled time frame. A significant effort from the author and the journal perhaps enables to strike an equilibrium to meet the professional expectations of the peers in the world of scientific publication. AIAN believes in safeguarding the privacy rights of human subjects. In order to comply with it, the journal instructs all authors when uploading the manuscript to also add the ethical clearance (human/animals)/ informed consent of subject in the manuscript. This applies to the study/case report that involves animal/human subjects/human specimens e.g. extracted tooth part/soft tissue for biopsy/in vitro analysis.