Impact of Polyhexanide Care Bundle on Surgical Site Infections in Paediatric and Neonatal Cardiac Surgery: A Propensity Score-Matched Retrospective Cohort Study

IF 2.6 3区医学 Q2 DERMATOLOGY

International Wound Journal Pub Date : 2025-06-12 DOI:10.1111/iwj.70710

Gianluca Castiello, Giuseppe Caravella, Greta Ghizzardi, Gianluca Conte, Arianna Magon, Tiziana Fiorini, Laurenzia Ferraris, Simona De Vecchi, Veronica Calorenne, Andreea Alina Andronache, Alessandro Varrica, Alessandro Giamberti, Antonio Saracino, Rosario Caruso

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引用次数: 0

Abstract

The primary aim of this study was to evaluate the impact of the polyhexamethylene biguanide (PHMB) care bundle on the occurrence rates of surgical site infections (SSIs) in paediatric and neonatal cardiac surgery, addressing a critical gap in paediatric-specific infection prevention protocols. A retrospective cohort study included patients under 18 years old who underwent cardiac surgery at IRCCS Policlinico San Donato. Cohort A (n = 117) received the PHMB care bundle from April to December 2023, while Cohort B (n = 801) received conventional care from September 2020 to March 2023. The 1:1 propensity score matching was used to balance covariates between cohorts, resulting in two comparable cohorts (Cohort A = 114 patients and Cohort B = 112). The study found a significant reduction in SSIs among patients receiving the PHMB care bundle compared with those receiving conventional care (1.8% vs. 7.1%, p = 0.048). The comprehensive nature of the PHMB care bundle, including educational programs, preoperative and postoperative antimicrobial treatments, and consistent application of best practices, was instrumental in achieving these outcomes. Implementing antimicrobial care bundles could significantly reduce SSIs in paediatric cardiac surgery. Future research is needed to refine the tested bundle with prospective approaches.

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聚己胺护理包对儿科和新生儿心脏手术手术部位感染的影响：一项倾向评分匹配的回顾性队列研究

本研究的主要目的是评估聚六亚甲基双胍（PHMB）护理包对儿科和新生儿心脏手术手术部位感染（ssi）发生率的影响，解决儿科特异性感染预防方案的关键空白。一项回顾性队列研究包括在圣多纳托icccs Policlinico接受心脏手术的18岁以下患者。队列A （n = 117）于2023年4月至12月接受PHMB护理包，而队列B （n = 801）于2020年9月至2023年3月接受常规护理。使用1:1倾向评分匹配来平衡队列之间的协变量，产生两个可比较的队列（队列A = 114例患者，队列B = 112例）。研究发现，与接受常规护理的患者相比，接受PHMB护理包的患者ssi发生率显著降低（1.8% vs. 7.1%, p = 0.048）。PHMB护理包的全面性，包括教育计划、术前和术后抗菌治疗以及一贯的最佳实践应用，有助于实现这些结果。实施抗菌护理包可显著减少小儿心脏手术中的ssi。未来的研究需要用前瞻性的方法来完善测试包。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Wound Journal DERMATOLOGY-SURGERY

CiteScore

4.50

自引率

12.90%

发文量

266

审稿时长

6-12 weeks

期刊介绍： The Editors welcome papers on all aspects of prevention and treatment of wounds and associated conditions in the fields of surgery, dermatology, oncology, nursing, radiotherapy, physical therapy, occupational therapy and podiatry. The Journal accepts papers in the following categories: - Research papers - Review articles - Clinical studies - Letters - News and Views: international perspectives, education initiatives, guidelines and different activities of groups and societies. Calendar of events The Editors are supported by a board of international experts and a panel of reviewers across a range of disciplines and specialties which ensures only the most current and relevant research is published.