Volumetric Nanodroplet-Enhanced Ultrasound Surgery Combined with Immune Checkpoint Inhibition as a Cancer Therapy Platform (Small 23/2025)

IF 13 2区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Small Pub Date : 2025-06-12 DOI:10.1002/smll.202570179

Bar Glickstein, Mike Bismuth, Roni Gattegno, Tiran Bercovici, Oz Shaul, Ramona Aronovich, Galit Horn, Anat Globerson Levin, Yi Feng, Tali Ilovitsh

引用次数: 0

Abstract

Cancer Therapy

In article number 2411474, Tali Ilovitsh and co-workers combine nanodroplet-mediated ultrasound surgery with checkpoint inhibition to enhance immunotherapy. Systemically injected nanodroplets accumulate in the tumor and are activated into cavitating gas bubbles using ultrasound imaging. Subsequent low-frequency ultrasound implodes the vaporized nanodroplets, inducing tumor fractionation and creating a T-cell–inflamed microenvironment. This approach integrates mechanical disruption with immune activation, addressing key barriers in solid tumor treatment.

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体积纳米微滴增强超声手术联合免疫检查点抑制作为癌症治疗平台（Small 23/2025）

癌症治疗在2411474号文章中，Tali Ilovitsh及其同事将纳米微滴介导的超声手术与检查点抑制相结合，以增强免疫治疗。系统注射的纳米液滴在肿瘤中积累，并通过超声成像激活成空化气泡。随后的低频超声将汽化的纳米液滴内爆，诱导肿瘤分离并创造一个t细胞炎症的微环境。这种方法结合了机械破坏和免疫激活，解决了实体瘤治疗的关键障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Small 工程技术-材料科学：综合

CiteScore

17.70

自引率

3.80%

发文量

1830

审稿时长

2.1 months

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