Apoptotic Vesicles Derived from Mesenchymal Stem Cells Ameliorate Hypersensitivity Responses via Inducing CD8+ T Cells Apoptosis with Calcium Overload and Mitochondrial Dysfunction (Adv. Sci. 22/2025)

IF 14.3 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Science Pub Date : 2025-06-12 DOI:10.1002/advs.202570169

Anqi Liu, Peng Peng, Changze Wei, Fanhui Meng, Xiaoyao Huang, Peisheng Liu, Siyuan Fan, Xinyue Cai, Meiling Wu, Zilin Xuan, Qing Liu, Xinyu Qiu, Zhenlai Zhu, Hao Guo

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引用次数: 0

Abstract

Apoptotic Vesicles-Based Cell-free Therapy

In article number 2407446, Hao Guo, Zhenlai Zhu, Xinyu Qiu, and colleagues introduce a novel therapeutic potential of apoptotic vesicles (ApoVs) for ameliorating hypersensitivity reactions through the induction of CD8⁺ T cell apoptosis. The cover illustrates that ApoVs derived from mesenchymal stem cells interact with CD8⁺ T cells via membrane fusion, triggering calcium influx, mitochondrial dysfunction, and ultimately apoptosis in CD8⁺ T cells. This study highlights the potential of products derived from apoptotic cells as a promising strategy for therapeutic applications in diseases involving CD8⁺ T cell-mediated pathologies.

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间充质干细胞的凋亡小泡通过诱导CD8+ T细胞凋亡、钙超载和线粒体功能障碍改善超敏反应（add . Sci. 22/2025）

基于凋亡小泡的无细胞治疗在文章编号2407446中，郭浩，朱振来，邱新宇等介绍了凋亡小泡（ApoVs）通过诱导CD8+ T细胞凋亡改善超敏反应的一种新的治疗潜力。封面说明来自间充质干细胞的ApoVs通过膜融合与CD8+ T细胞相互作用，触发钙内流，线粒体功能障碍，最终导致CD8+ T细胞凋亡。这项研究强调了来自凋亡细胞的产品作为一种有希望的治疗策略应用于涉及CD8+ T细胞介导病理的疾病的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.