Ultrasound Guided Local Delivery of Bioorthogonal PDL1 Degrader for Enhanced Immunotherapy (Small 23/2025)

IF 13 2区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Small Pub Date : 2025-06-12 DOI:10.1002/smll.202570177

Lantian Wang, Zhaoyou Liu, Panpan Ji, Jiao Ma, Ke Mou, Tian Zhou, Yuan Liang, Bin Zhang, Mengying Wei, Guodong Yang, Wenqi Sun, Li Gong, Lijun Yuan

引用次数: 0

Abstract

Immunotherapy

In article number 2405549, Wenqi Sun, Li Gong, Lijun Yuan, and co-workers have designed a nanodroplet for targeted PDL1 degradation in the tumor region. The nanodroplet is endowed with the capacities to accumulate in the ocean of tumor vessels and be visible by ultrasound, serving as a submarine. Moreover, ultrasound could launch the biorthogonal PD1 armed missiles on the “submarine”, and the missiles in turn lock onto PDL1 and destroy it to unleash anti-tumor immunity.

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超声引导下局部递送生物正交PDL1降解剂增强免疫治疗（小23/2025）

免疫治疗在文章编号2405549中，孙文琪，龚丽，袁丽君等人设计了一种靶向肿瘤区域PDL1降解的纳米液滴。这种纳米液滴被赋予了在肿瘤血管的海洋中积累的能力，并且可以通过超声波看到，就像潜艇一样。此外，超声波可以在“潜艇”上发射双正交PD1武装导弹，导弹依次锁定PDL1并摧毁它以释放抗肿瘤免疫。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Small 工程技术-材料科学：综合

CiteScore

17.70

自引率

3.80%

发文量

1830

审稿时长

2.1 months

期刊介绍： Small serves as an exceptional platform for both experimental and theoretical studies in fundamental and applied interdisciplinary research at the nano- and microscale. The journal offers a compelling mix of peer-reviewed Research Articles, Reviews, Perspectives, and Comments. With a remarkable 2022 Journal Impact Factor of 13.3 (Journal Citation Reports from Clarivate Analytics, 2023), Small remains among the top multidisciplinary journals, covering a wide range of topics at the interface of materials science, chemistry, physics, engineering, medicine, and biology. Small's readership includes biochemists, biologists, biomedical scientists, chemists, engineers, information technologists, materials scientists, physicists, and theoreticians alike.