Cancer in persons diagnosed with facial nerve paresis: A hospital-based cohort study in Denmark

IF 2.4 3区医学 Q3 ONCOLOGY

Cancer Epidemiology Pub Date : 2025-06-11 DOI:10.1016/j.canep.2025.102863

Holly Elser , Dóra Körmendiné Farkas , Lindsay J. Collin , Malene Risager Lykke , Cecilia Hvitfeldt Fuglsang , Henrik Toft Sørensen

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Abstract

Background

Neoplasms can compress or infiltrate the facial nerve, leading to facial nerve paresis or palsy (FNP). As evidence regarding cancers outside the head, neck, and nervous system in persons initially diagnosed with FNP remains limited, we examined the overall and site-specific cancer rates among all patients diagnosed with FNP in Denmark over a 29-year study period.

Methods

We conducted a hospital-based cohort study in Denmark, 1994–2022, identifying FNP from inpatient, outpatient, or emergency room visits. We computed absolute risks (AR), and age- and sex-standardized incidence ratios (SIR) with corresponding 95 % confidence intervals (CIs) for all cancers, cancer groups, and site-specific cancers diagnosed <1 year and ≥1 after FNP diagnosis.

Results

There were 27,147 recorded diagnoses of FNP. For cancers diagnosed <1 year after FNP, the AR was 1.67 % (95 %CI: 1.53,1.83) and the SIR was 2.62 (95 %CI: 2.38,2.87) with strong associations for cancers of the nervous system (SIR=14.7, 95 %CI: 12.1,17.7) and head and neck (SIR = 8.37, 95 %CI: 6.41,10.7). For cancers diagnosed ≥1 year after FNP, the AR was 20.2 % (95 %CI: 18.0,22.6) and the SIR was 1.08 (95 %CI: 1.04,1.13) with persistent associations for cancers of the salivary gland (SIR=2.43, 95 %CI: 1.11,4.62), brain (SIR = 1.48, 95 %CI: 1.16,1.86), spinal cord, cranial nerves, and other parts of the central nervous system (SIR = 1.83, 95 %CI: 1.22,2.62), liver (SIR = 2.02, 95 %CI: 1.50,2.65), and anus (SIR = 1.94, 95 %CI: 1.09,3.20).

Conclusion

Rates of local cancers remained persistently elevated among persons diagnosed with FNP as compared with the Danish general population, as did rates of distant cancers implying a key role for metastatic disease as an underlying cause of FNP. Research that explores these associations by cancer stage may yield additional insight into these observed associations.

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面神经麻痹患者的癌症：丹麦一项基于医院的队列研究

肿瘤可压迫或浸润面神经，导致面神经麻痹或麻痹（FNP）。由于最初诊断为FNP的人头颈和神经系统以外的癌症证据仍然有限，我们在丹麦29年的研究期间检查了所有诊断为FNP的患者的总体和部位特异性癌症发病率。方法：1994-2022年，我们在丹麦进行了一项以医院为基础的队列研究，从住院、门诊或急诊室就诊中识别FNP。我们计算了FNP诊断后1年和≥1年的所有癌症、癌症组和部位特异性癌症的绝对风险（AR）、年龄和性别标准化发病率（SIR）以及相应的95% %置信区间（CIs）。结果FNP确诊27147例。对于FNP后1年确诊的癌症，AR为1.67 %(95 %CI: 1.53,1.83)， SIR为2.62(95 %CI: 2.38,2.87)，与神经系统癌症（SIR=14.7, 95 %CI: 12.1,17.7）和头颈部癌症（SIR = 8.37,95 %CI: 6.41,10.7）有很强的相关性。癌症诊断≥1年之后——基于“增大化现实”技术为20.2 %(95 % CI: 18.0, 22.6),爵士1.08(95 % CI: 1.04、1.13)与持久的关联唾腺癌(爵士= 2.43,95 % CI: 1.11, 4.62),大脑( = 1.48爵士95 % CI: 1.16, 1.86),脊髓,颅神经,和中枢神经系统的其他部分( = 1.83爵士95 % CI: 1.22, 2.62),肝脏( = 2.02爵士95 % CI: 1.50, 2.65),和肛门( = 1.94爵士95 % CI: 1.09, 3.20)。结论：与丹麦普通人群相比，诊断为FNP的患者中局部癌症的发生率持续升高，远处癌症的发生率也持续升高，这意味着转移性疾病是FNP的潜在原因。通过癌症分期探索这些关联的研究可能会对这些观察到的关联产生更多的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Epidemiology 医学-肿瘤学

CiteScore

4.50

自引率

3.80%

发文量

200

审稿时长

39 days

期刊介绍： Cancer Epidemiology is dedicated to increasing understanding about cancer causes, prevention and control. The scope of the journal embraces all aspects of cancer epidemiology including: • Descriptive epidemiology • Studies of risk factors for disease initiation, development and prognosis • Screening and early detection • Prevention and control • Methodological issues The journal publishes original research articles (full length and short reports), systematic reviews and meta-analyses, editorials, commentaries and letters to the editor commenting on previously published research.