First insights into the genetic composition of M. tuberculosis population circulating in Kosovo

IF 1.9 Q3 INFECTIOUS DISEASES

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases Pub Date : 2025-06-07 DOI:10.1016/j.jctube.2025.100537

Alina Minias , Magdalena Kuzioła , Florin Ahmeti , Nazmi Mehmeti , Blendi Jerliu , Greta Lila , Albuena Miftari , Xhevat Shkodra , Xhevat Jakupi , Zana Kacaniku , Monika Kozińska , Anna Zabost , Marcin Słomka , Dominik Strapagiel , Jarosław Dziadek , Ewa Augustynowicz-Kopeć , Rrezarta Bajrami

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引用次数: 0

Abstract

Tuberculosis incidence in Kosovo is among one of the highest in Europe at 33/100,000 citizens. While World Health Organization encourages epidemiological monitoring of tuberculosis transmission, studies regarding M. tuberculosis population structure in the Balkan region are limited. Here, we used spoligotyping and whole genome sequencing to describe the variation of M. tuberculosis strains circulating in Kosovo. We used samples isolated from patients in the period 2021/2022. We found that the vast majority of isolated strains belonged to spoligotype based Euro-American lineage, five strains belonged to East-Asian lineage, and one was M. caprae. We described the general characteristics of the M. tuberculosis population in our study and identified chains of transmission based on whole genome sequencing data of selected samples. Our data will be a reference point for subsequent studies of M. tuberculosis population in Kosovo.

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首次深入了解科索沃流行的结核分枝杆菌人群的遗传组成

科索沃的结核病发病率是欧洲最高的国家之一，为每10万人中有33人。虽然世界卫生组织鼓励对结核病传播进行流行病学监测，但关于巴尔干地区结核分枝杆菌人口结构的研究有限。在这里，我们使用spoligotyping和全基因组测序来描述在科索沃流行的结核分枝杆菌菌株的变异。我们使用了2021/2022年期间从患者中分离的样本。我们发现绝大多数分离菌株属于基于spoligotype的欧美谱系，5株属于东亚谱系，1株为M. caprae。在我们的研究中，我们描述了结核分枝杆菌人群的一般特征，并根据选定样本的全基因组测序数据确定了传播链。我们的数据将成为科索沃结核分枝杆菌人群后续研究的参考点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases Medicine-Pulmonary and Respiratory Medicine

CiteScore

4.00

自引率

5.00%

发文量

审稿时长

30 weeks

期刊介绍： Journal of Clinical Tuberculosis and Mycobacterial Diseases aims to provide a forum for clinically relevant articles on all aspects of tuberculosis and other mycobacterial infections, including (but not limited to) epidemiology, clinical investigation, transmission, diagnosis, treatment, drug-resistance and public policy, and encourages the submission of clinical studies, thematic reviews and case reports. Journal of Clinical Tuberculosis and Mycobacterial Diseases is an Open Access publication.