Breed predispositions and malignancy analysis for canine tumors: A multicenter histopathological retrospective study from Central Italy

IF 2.2 3区农林科学 Q1 VETERINARY SCIENCES

Research in veterinary science Pub Date : 2025-06-06 DOI:10.1016/j.rvsc.2025.105752

Niccolò Fonti , Azzurra Carnio , Cristiano Cocumelli , Elena Sophie Dhein , Claudia Eleni , Valentina Galietta , Franco Guscetti , Alessio Lachi , Francesca Parisi , Alessandro Poli , Paola Scaramozzino , Francesca Millanta

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引用次数: 0

Abstract

Animal Cancer Registries (ACRs) enhance our understanding of oncology by providing insights into epidemiologic and clinical trends and fostering comparative research. This study analyzed a large dataset of canine tumors, evaluating their distribution and malignancy profiles by breed, sex, neuter status, age, and district of origin. Histologically diagnosed tumors from two pathology-based ACRs in central Italy (2008–2023) were coded using Vet-ICD-O-canine-1. Logistic regression assessed the influence of variables on tumor behavior, modeled as a binary outcome (“malignant” vs “benign”). Of 26,218 tumors, 41.6 % were benign and 58.4 % malignant. Malignancy risk increased by 8 % per year of age. Females had higher risk of malignancy (OR = 2.16; 95 %CI 2.04–2.29). Neuter status didn't affect malignancy risk (OR = 1.02; 95 %CI 0.96–1.09) but influenced risk for specific tumor groups. Highest malignancy risk was in Dogo Argentinos (OR = 2.18; 95 %CI 1.49–3.25), Rottweilers (OR = 2.00; 95 %CI 1.56–2.57), Pugs (OR = 1.99; 95 %CI 1.38–2.92), and Doberman Pinschers (OR = 1.79; 95 %CI 1.35–2.40); lowest in West Highland White Terriers (OR = 0.54; 95 %CI 0.38–0.76), Siberian Huskies (OR = 0.66; 95 %CI 0.49–0.90), Cocker Spaniels (OR = 0.69; 95 %CI 0.58–0.83), and Poodles (OR = 0.72; 95 %CI 0.60–0.87). Potential new predispositions emerged in Cane Corsos (lymphomas, basal cell tumors, histiocytic tumors) and Maremma Sheepdogs (odontogenic, adnexal, and skin appendage neoplasms). This study confirms known patterns, reveals novel risk factors, and highlights the importance of multicenter collaboration in identifying high-risk oncology patients.

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犬肿瘤的品种易感性和恶性分析：一项来自意大利中部的多中心组织病理学回顾性研究

动物癌症登记处（ACRs）通过提供流行病学和临床趋势的见解以及促进比较研究，增强了我们对肿瘤学的理解。本研究分析了犬肿瘤的大量数据集，根据品种、性别、中性状态、年龄和原产地区评估了它们的分布和恶性特征。使用Vet-ICD-O-canine-1对意大利中部（2008-2023）两个基于病理的acr的组织学诊断肿瘤进行编码。Logistic回归评估变量对肿瘤行为的影响，建模为二元结果（“恶性”vs“良性”）。在26218例肿瘤中，41.6%为良性，58.4%为恶性。恶性肿瘤风险每年增加8%。女性患恶性肿瘤的风险较高(OR = 2.16；95% ci 2.04-2.29)。中性状态不影响恶性肿瘤风险(OR = 1.02；95% CI 0.96-1.09)，但影响特定肿瘤组的风险。恶性肿瘤风险最高的是阿根廷多戈人(OR = 2.18；95% CI 1.49-3.25)，罗威纳犬(OR = 2.00；95% CI 1.56-2.57), Pugs (OR = 1.99；95% CI 1.38-2.92)，杜宾犬(OR = 1.79；95% ci 1.35-2.40)；西高地白梗最低(OR = 0.54；95% CI 0.38-0.76)，西伯利亚哈士奇(OR = 0.66；95% CI 0.49-0.90)，可卡犬(OR = 0.69；95% CI 0.58-0.83)和贵宾犬(OR = 0.72；95% ci 0.60-0.87)。潜在的新倾向出现在甘蔗犬（淋巴瘤、基底细胞肿瘤、组织细胞肿瘤）和Maremma牧羊犬（牙源性、附件和皮肤附件肿瘤）中。这项研究证实了已知的模式，揭示了新的危险因素，并强调了多中心合作在识别高危肿瘤患者中的重要性。

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来源期刊

Research in veterinary science 农林科学-兽医学

CiteScore

4.40

自引率

4.20%

发文量

312

审稿时长

75 days

期刊介绍： Research in Veterinary Science is an International multi-disciplinary journal publishing original articles, reviews and short communications of a high scientific and ethical standard in all aspects of veterinary and biomedical research. The primary aim of the journal is to inform veterinary and biomedical scientists of significant advances in veterinary and related research through prompt publication and dissemination. Secondly, the journal aims to provide a general multi-disciplinary forum for discussion and debate of news and issues concerning veterinary science. Thirdly, to promote the dissemination of knowledge to a broader range of professions, globally. High quality papers on all species of animals are considered, particularly those considered to be of high scientific importance and originality, and with interdisciplinary interest. The journal encourages papers providing results that have clear implications for understanding disease pathogenesis and for the development of control measures or treatments, as well as those dealing with a comparative biomedical approach, which represents a substantial improvement to animal and human health. Studies without a robust scientific hypothesis or that are preliminary, or of weak originality, as well as negative results, are not appropriate for the journal. Furthermore, observational approaches, case studies or field reports lacking an advancement in general knowledge do not fall within the scope of the journal.