Decoding Molecular Interactions of Glycine, l-Proline, and l-valine in Aqueous Solution of Anti Alzheimer DRUG Donepezil Hydrochloride: A Volumetric, Acoustic, and Viscometric Approach

Abstract

This research study offers an extensive exploration of how Donepezil hydrochloride (DonHCl) behaves within aqueous surroundings, particularly in the company of three key primary amino acids: glycine (GLY), l-proline (PRO), and l-valine (VAL). This research encompasses a temperature range from 288.15 to 318.15 K involving volumetric, acoustic, and viscometric measurements to investigate the interplay between DonHCl and the amino acids, unraveling their complexities and nuances. The comprehensive computation and analysis of various thermodynamic parameters under study, including the limiting apparent molar volume of solute (V_ϕ⁰) and the associated experimental slope (S_V), along with the Jones–Dole B-coefficient, highlight the paramount significance of solute–solvent associations within amino acid-aqueous DonHCl solutions. Additionally, computations have been carried out for the coefficient of thermal expansion (α*), Hepler’s constant (∂²V_ϕ⁰/∂T²), and the temperature derivative of the B coefficient (dB/dT). The findings shed light on the interactions among these amino acids and the drug DonHCl influenced by temperature, providing insights into potential binding mechanisms and solution behavior. This study has implications for the pharmaceutical sciences, where DonHCl is crucial, in addition to improving our fundamental knowledge of solute–solvent interactions. This study presents a novel investigation into DonHCl, marking a new research endeavor in the field.