Solubility of Oxfendazole in 8 Pure Solvents and 2 Binary Solvents from 278.15 to 323.15 K

Abstract

Oxfendazole is a broad-spectrum anthelmintic that belongs to the class of benzimidazole derivatives. This study determined the solubility of oxfendazole in eight pure solvents (methanol, 2-methoxyethanol, 2-ethoxyethanol, 2-propoxyethanol, diglyme, DMSO, DMF, and DMAC) and two binary mixed solvents (DMSO + ethanol and DMSO + acetone) over the temperature range of 278.15 to 323.15 K (with 5 K intervals). The results indicate that the solubility of oxfendazole in the selected solvents is positively correlated with the system temperature, and in the binary solvent systems, the solubility decreases with increasing mass fraction of the antisolvent. Furthermore, the measured solubility data were correlated using the modified Apelblat equation, λh model, Jouyban-Acree model, NRTL model, and UNIQUAC model, resulting in a good correlation between the predicted values and experimental values, with the modified Apelblat equation demonstrating the best correlated performance.