Pd-Catalyzed C-H Activation and Oxidative Annulation to Access N-methoxy-7H-Chromenoquinolinones and N-methoxyphenyl quinolinones

Abstract

The palladium-catalyzed oxidative annulation of N-methoxy-2H-chromene-3-carboxamides and N-methoxycinnamamides with benzynes via C-H functionalization to synthesize N-methoxy-7H-Chromenoquinolinones and N-methoxyphenylquinolinones have been developed successfully. The reaction demonstrates broad compatibility with different substrates, high tolerance for various functional groups, and excellent regioselectivity. By carefully selecting substituted arynes, exceptional regioselectivity can be achieved. The structure of a key product was confirmed through X-ray crystallography, further validating the efficiency and success of the reaction.