Vitamin C as a Serum Uric Acid Lowering Agent in Hyperuricaemia.

IF 0.8
Iqra Siddiqui, Moosa Khan, Faiza Rehman, Maleeha Abbas, Shahnawaz Jamali
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Abstract

Objective: To assess the impact of Vitamin C supplementation compared to Allopurinol therapy on the modulation of serum uric acid levels in individuals diagnosed with hyperuricaemia.

Study design: A comparative analytical study. Place and Duration of the Study: Department of Pharmacology and Therapeutics, Shaheed Zulfiqar Ali Bhutto Medical University, in collaboration with the Department of Medicine and Rheumatology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan, from May to December, 2023.

Methodology: Eighty-six hyperuricaemic patients were enrolled and segregated equally into two groups. Group 1 received Allopurinol while Group 2 received Allopurinol plus Vitamin C. Serum uric acid levels at days 0, 30, and 60 were monitored for the serum uric acid-lowering effect of medicines. Frequency and percentages were presented for qualitative variables such as gender and age. An independent t-test was applied to compare the serum uric acid level at different intervals between both groups. A p-value equal to or less than <0.05 was considered statistically significant.

Results: The Allopurinol Group's baseline serum uric acid level was 8.321 ± 0.097 mg/dl, and the baseline value of serum uric acid of Allopurinol plus Vitamin C was 8.547 ± 0.101 mg/dl. At day 60th, the mean serum uric acid level in the Allopurinol group was 7.524 ± 0.097 with p <0.001. In the Vitamin C plus Allopurinol group, the mean serum uric acid level was 6.371 ± 0.161 with a p-value <0.001. In the Allopurinol plus vitamin C group, the percentage reduction in serum uric acid level was more than 25.44% as compared to the Allopurinol group of 9.51%.

Conclusion: Vitamin C used with Allopurinol as an adjunct therapy is a more potent pharmacological strategy for lowering blood uric acid levels in hyperuricaemic patients than alone.

Key words: Hyperuricaemia, Vitamin C, Allopurinol, Uric acid.

维生素C作为高尿酸血症的血清降尿酸剂。
目的:评估维生素C补充与别嘌呤醇治疗对高尿酸血症患者血清尿酸水平调节的影响。研究设计:比较分析研究。研究地点和时间:2023年5月至12月,Shaheed Zulfiqar Ali Bhutto医科大学药理学和治疗学系与巴基斯坦医学科学研究所医学和风湿病学系合作,巴基斯坦伊斯兰堡。方法:86例高尿酸血症患者被平均分为两组。组1给予别嘌呤醇治疗,组2给予别嘌呤醇加维生素c治疗。监测第0、30、60天血清尿酸水平,观察药物降尿酸效果。频率和百分比为定性变量,如性别和年龄。采用独立t检验比较两组不同时间间隔的血尿酸水平。结果:别嘌呤醇组血清尿酸基线值为8.321±0.097 mg/dl,别嘌呤醇加维生素C组血清尿酸基线值为8.547±0.101 mg/dl。在第60天,别嘌呤醇组的平均血清尿酸水平为7.524±0.097 (p)。结论:维生素C与别嘌呤醇联合使用是降低高尿酸血症患者血尿酸水平的更有效的药物策略。关键词:高尿酸血症,维生素C,别嘌呤醇,尿酸
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