[A case of pulmonary nodules and cysts associated with hypereosinophilia].

Abstract

A 56-year-old male patient presented with an 18-year history of pulmonary opacities and a 9-year history of hypereosinophilia. The patient was asymptomatic. Bronchoscopy was negative for pathogens. Serial chest radiographs showed stable lung lesions. Nine years ago, an elevated blood eosinophil count [(0.5-1.5)×10⁹/L] was noted. A chest computed tomography (CT) scan showed multiple nodules and cysts in bilateral lungs, which were not investigated further. Two weeks before admission, a follow-up chest CT scan demonstrated slight enlargement and an increase in the number of pulmonary nodules and cysts. Bronchoscopy was again unremarkable. Surgical lung biopsy confirmed the diagnosis of multicentric Castleman disease. This case highlighted the importance of comprehensive clinical evaluation and multidisciplinary collaboration in the diagnosis of unusual pulmonary manifestations.