Influence of Overnight Orthokeratology on Ocular Surface and Blink Patterns in Children and Adolescents-A Prospective Cohort Study.

IF 2.1 4区医学 Q2 OPHTHALMOLOGY

Eye & Contact Lens-Science and Clinical Practice Pub Date : 2025-06-06 DOI:10.1097/ICL.0000000000001197

Jun Feng, Yixuan Gu, Ya Wen, Yinghui Wang, Jingyi Wang, Ao Li, Yiran Hao, Qian Li, Wenhua Wang, Lei Tian, Ying Jie

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Abstract

Objectives: To investigate the effect of overnight orthokeratology (OOK) on ocular surface and blinking patterns in children and adolescents.

Methods: A prospective cohort study was conducted including 27 eyes of 27 children from Beijing Tongren Hospital who received OOK correction and 31 eyes of 31 spectacle wearing children. Tests were performed before and at 3 and 6 months after OOK wear. Ocular surface assessment included tear meniscus height, noninvasive tear breakup time, lipid layer thickness, number of incomplete blinks, number of total blinks, and fluorescein tear breakup time.

Results: Before treatment, there were no statistically significant differences in various indicators between the two groups. After wearing OOK for 3 months and 6 months, there were no significant differences between the tear meniscus height, noninvasive tear breakup time, lipid layer thickness, number of incomplete and total blinks, fluorescein tear breakup time groups, and upper and lower lid meibomian gland atrophy rate ( P >0.05). However, the corneal fluorescein staining scores in the OOK group were significantly higher than those in the spectacle group ( P <0.001).

Conclusions: Short-term use of OOK in children and adolescents has a relatively minor impact on ocular surfaces and is considered relatively safe to use. However, it significantly increases corneal fluorescein staining scores, which may suggest the presence of corneal epithelial damage.

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夜间角膜塑形术对儿童和青少年眼表和眨眼模式的影响——一项前瞻性队列研究。

目的：探讨夜间角膜塑形术（OOK）对儿童青少年眼表及眨眼模式的影响。方法：采用前瞻性队列研究，选取北京同仁医院27例接受OOK矫正的患儿27只眼和31例配戴眼镜的患儿31只眼。在OOK磨损前、3个月和6个月分别进行测试。眼表评估包括泪液半月板高度、无创泪液破裂时间、脂质层厚度、不完全眨眼次数、总眨眼次数和荧光素泪液破裂时间。结果：治疗前，两组患者各项指标比较，差异均无统计学意义。佩戴OOK 3个月和6个月后，泪膜半月板高度、无创撕裂时间、脂质层厚度、完全和不完全眨眼次数、荧光素撕裂时间组、上、下眼睑睑板腺萎缩率差异无统计学意义（P < 0.05）。然而，OOK组角膜荧光素染色评分明显高于眼镜组(p结论：儿童和青少年短期使用OOK对眼表的影响相对较小，使用相对安全。然而，它显著增加了角膜荧光素染色评分，这可能提示存在角膜上皮损伤。

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来源期刊

Eye & Contact Lens-Science and Clinical Practice OPHTHALMOLOGY-

CiteScore

4.50

自引率

4.30%

发文量

150

审稿时长

6-12 weeks

期刊介绍： Eye & Contact Lens: Science and Clinical Practice is the official journal of the Contact Lens Association of Ophthalmologists (CLAO), an international educational association for anterior segment research and clinical practice of interest to ophthalmologists, optometrists, and other vision care providers and researchers. Focusing especially on contact lenses, it also covers dry eye disease, MGD, infections, toxicity of drops and contact lens care solutions, topography, cornea surgery and post-operative care, optics, refractive surgery and corneal stability (eg, UV cross-linking). Peer-reviewed and published six times annually, it is a highly respected scientific journal in its field.