Congenital diaphragmatic hernia with congenital heart disease including ventricular septal defect: Risk factors.

IF 1 4区医学 Q3 PEDIATRICS

Pediatrics International Pub Date : 2025-01-01 DOI:10.1111/ped.70126

Yuichi Hirano, Keita Terui, Wataru Kudo, Ayako Takenouchi, Shugo Komatsu, Satoru Oita, Hiroko Yoshizawa, Takashi Fumita, Yusaku Yoshino, Tomoro Hishiki

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引用次数: 0

Abstract

Background: Congenital diaphragmatic hernia (CDH) with congenital heart disease (CHD) has a poor prognosis. This study aimed to establish the prognostic factors of CDH associated with ventricular septal defect (VSD), which is the most commonly encountered CHD.

Methods: We conducted a single-center, retrospective observational study including neonatal cases of CDH with CHD managed at our hospital between 2000 and 2022. The risk factors for CDH in patients with VSD were established by comparing survivors and non-survivors.

Results: Among the 84 infants with CDH, 14 (17%) were associated with CHD, including 11 cases of VSD (79% of CHD). The survival rate of patients with CDH prenatally diagnosed with left-sided disease and VSD was 56% (four of nine patients died). The rate of low lung volume (observed/expected lung area-to-head circumference ratio ≤ 35%) was significantly higher in non-survivors than in survivors (75% vs. 0%, p = 0.048). All non-survivors had associated severe CHD (n = 3) or severe pulmonary hypertension (n = 1).

Conclusion: Low lung volume was a risk factor for CDH with at least moderate to small size of VSD, which was comparable with that in patients with isolated CDH.

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先天性膈疝合并先天性心脏病包括室间隔缺损：危险因素。

背景：先天性膈疝合并先天性心脏病预后较差。本研究旨在确定室间隔缺损（VSD）相关的CDH预后因素，VSD是最常见的冠心病。方法：我们进行了一项单中心、回顾性观察性研究，包括2000年至2022年在我院治疗的新生儿CDH合并冠心病病例。通过比较幸存者和非幸存者，确定VSD患者CDH的危险因素。结果：84例CDH患儿中，14例（17%）合并冠心病，其中VSD 11例（79%）。产前诊断为左侧疾病和VSD的CDH患者的生存率为56%（9例患者中有4例死亡）。低肺体积率（观察到的/预期的肺面积与头围比≤35%）在非幸存者中显著高于幸存者（75%比0%，p = 0.048）。所有非幸存者均伴有严重冠心病（n = 3）或严重肺动脉高压（n = 1）。结论：低肺容量是CDH发生的危险因素，至少伴有中度至小室间隔，这与孤立性CDH患者的危险因素相当。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatrics International 医学-小儿科

CiteScore

2.00

自引率

7.10%

发文量

519

审稿时长

12 months

期刊介绍： Publishing articles of scientific excellence in pediatrics and child health delivery, Pediatrics International aims to encourage those involved in the research, practice and delivery of child health to share their experiences, ideas and achievements. Formerly Acta Paediatrica Japonica, the change in name in 1999 to Pediatrics International, reflects the Journal''s international status both in readership and contributions (approximately 45% of articles published are from non-Japanese authors). The Editors continue their strong commitment to the sharing of scientific information for the benefit of children everywhere. Pediatrics International opens the door to all authors throughout the world. Manuscripts are judged by two experts solely upon the basis of their contribution of original data, original ideas and their presentation.