Acquisition matters - how do scan parameters affect apparent diffusion coefficient estimates in pediatric rhabdomyosarcoma.

IF 2.3 3区医学 Q2 PEDIATRICS

Pediatric Radiology Pub Date : 2025-07-01 Epub Date: 2025-06-10 DOI:10.1007/s00247-025-06263-w

Cyrano Chatziantoniou, Roelof van Ewijk, Madeleine Adams, Patrizia Bertolini, Gianni Bisogno, Amine Bouhamama, Pablo Caro-Dominguez, Valérie Charon, Ana Coma, Rana Dandis, Christine Devalck, Giulia De Donno, Andrea Ferrari, Marta Fiocco, Soledad Gallego, Chiara Giraudo, Heidi Glosli, Simone A J Ter Horst, Meriel Jenney, Willemijn M Klein, Alexander Leemans, Julie Leseur, Henry C Mandeville, Kieran McHugh, Johannes H M Merks, Veronique Minard-Colin, Salma Moalla, Carlo Morosi, Daniel Orbach, Lil-Sofie Ording Müller, Erika Pace, Pier Luigi Di Paolo, Katia Perruccio, Lucia Quaglietta, Marleen Renard, Rick R van Rijn, Antonio Ruggiero, Sara I Sirvent, Reineke A Schoot, Alberto De Luca

{"title":"Acquisition matters - how do scan parameters affect apparent diffusion coefficient estimates in pediatric rhabdomyosarcoma.","authors":"Cyrano Chatziantoniou, Roelof van Ewijk, Madeleine Adams, Patrizia Bertolini, Gianni Bisogno, Amine Bouhamama, Pablo Caro-Dominguez, Valérie Charon, Ana Coma, Rana Dandis, Christine Devalck, Giulia De Donno, Andrea Ferrari, Marta Fiocco, Soledad Gallego, Chiara Giraudo, Heidi Glosli, Simone A J Ter Horst, Meriel Jenney, Willemijn M Klein, Alexander Leemans, Julie Leseur, Henry C Mandeville, Kieran McHugh, Johannes H M Merks, Veronique Minard-Colin, Salma Moalla, Carlo Morosi, Daniel Orbach, Lil-Sofie Ording Müller, Erika Pace, Pier Luigi Di Paolo, Katia Perruccio, Lucia Quaglietta, Marleen Renard, Rick R van Rijn, Antonio Ruggiero, Sara I Sirvent, Reineke A Schoot, Alberto De Luca","doi":"10.1007/s00247-025-06263-w","DOIUrl":null,"url":null,"abstract":"Background: The apparent diffusion coefficient (ADC) derived from diffusion-weighted imaging (DWI) is a potential biomarker for treatment response in pediatric rhabdomyosarcoma. Due to its rarity, investigations into this marker require multicenter approaches, which can result in variability in acquisition parameters.Objective: To evaluate the impact of different acquisition parameters on ADC estimates in a multicenter dataset of rhabdomyosarcoma patients.Materials and methods: We included 114 pediatric and adolescent rhabdomyosarcoma patients from 22 treatment centers (195 scans). Median age: 6.0 years (0.3-21.8). We evaluated the impact of voxel size, (number of) b-values, and echo time on tumor ADC values. The effect of the highest b-value was separately investigated on a subset of scans with five or more b-values.Results: We observed a large variability in key acquisition parameters in the overall cohort, and for individual imaging centers. No parameter showed a significant effect on ADC estimates of the whole cohort when corrected for multiple-comparisons. Decreasing the highest b-value within the same acquisition caused ADC to decrease on average by 2.8% per 100 s mm-2. Differing b-values between scans at diagnosis and treatment response yielded significant changes in the longitudinal ADC for each patient (P<0.05).Conclusion: While we observed wide variation of acquisition parameters within a multicenter cohort, this did not lead to significant cross-sectional differences of tumor ADC. However, we found that modifying the highest b-value between baseline and follow-up can impact longitudinal ADC estimates. As such, we recommend the highest b-value to remain constant. This retrospective study was reviewed and approved by the Internal Review Board (UMC Utrecht, reference ID: 18-412).","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":"1598-1610"},"PeriodicalIF":2.3000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321683/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Radiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00247-025-06263-w","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/10 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"PEDIATRICS","Score":null,"Total":0}

引用次数: 0

Abstract

Background: The apparent diffusion coefficient (ADC) derived from diffusion-weighted imaging (DWI) is a potential biomarker for treatment response in pediatric rhabdomyosarcoma. Due to its rarity, investigations into this marker require multicenter approaches, which can result in variability in acquisition parameters.

Objective: To evaluate the impact of different acquisition parameters on ADC estimates in a multicenter dataset of rhabdomyosarcoma patients.

Materials and methods: We included 114 pediatric and adolescent rhabdomyosarcoma patients from 22 treatment centers (195 scans). Median age: 6.0 years (0.3-21.8). We evaluated the impact of voxel size, (number of) b-values, and echo time on tumor ADC values. The effect of the highest b-value was separately investigated on a subset of scans with five or more b-values.

Results: We observed a large variability in key acquisition parameters in the overall cohort, and for individual imaging centers. No parameter showed a significant effect on ADC estimates of the whole cohort when corrected for multiple-comparisons. Decreasing the highest b-value within the same acquisition caused ADC to decrease on average by 2.8% per 100 s mm^-2. Differing b-values between scans at diagnosis and treatment response yielded significant changes in the longitudinal ADC for each patient (P<0.05).

Conclusion: While we observed wide variation of acquisition parameters within a multicenter cohort, this did not lead to significant cross-sectional differences of tumor ADC. However, we found that modifying the highest b-value between baseline and follow-up can impact longitudinal ADC estimates. As such, we recommend the highest b-value to remain constant. This retrospective study was reviewed and approved by the Internal Review Board (UMC Utrecht, reference ID: 18-412).

Abstract Image

查看原文本刊更多论文

获取至关重要-扫描参数如何影响小儿横纹肌肉瘤的表观扩散系数估计。

背景：来自弥散加权成像（DWI）的表观弥散系数（ADC）是儿童横纹肌肉瘤治疗反应的潜在生物标志物。由于其稀有性，对该标记的研究需要多中心方法，这可能导致获取参数的可变性。目的：评估不同采集参数对横纹肌肉瘤患者多中心数据集中ADC估计的影响。材料和方法：我们纳入了来自22个治疗中心的114名儿童和青少年横纹肌肉瘤患者（195次扫描）。中位年龄：6.0岁（0.3-21.8岁）。我们评估了体素大小、b值（数目）和回波时间对肿瘤ADC值的影响。在具有5个或更多b值的扫描子集上，分别研究了最高b值的影响。结果：我们观察到在整个队列和单个成像中心的关键采集参数有很大的差异。经多重比较校正后，没有参数显示对整个队列的ADC估计值有显著影响。降低同一采集范围内的最高b值导致ADC每100 s mm-2平均下降2.8%。诊断和治疗反应时扫描的不同b值导致每个患者纵向ADC的显著变化(结论：虽然我们在多中心队列中观察到采集参数的广泛变化，但这并未导致肿瘤ADC的显著横断面差异。然而，我们发现修改基线和随访之间的最高b值会影响纵向ADC估计。因此，我们建议保持最高的b值不变。这项回顾性研究由内部审查委员会（UMC Utrecht，参考ID: 18-412）审查和批准。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Pediatric Radiology 医学-核医学

CiteScore

4.40

自引率

17.40%

发文量

300

审稿时长

3-6 weeks

期刊介绍： Official Journal of the European Society of Pediatric Radiology, the Society for Pediatric Radiology and the Asian and Oceanic Society for Pediatric Radiology Pediatric Radiology informs its readers of new findings and progress in all areas of pediatric imaging and in related fields. This is achieved by a blend of original papers, complemented by reviews that set out the present state of knowledge in a particular area of the specialty or summarize specific topics in which discussion has led to clear conclusions. Advances in technology, methodology, apparatus and auxiliary equipment are presented, and modifications of standard techniques are described. Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted.