Topoisomerase II Inhibition in Cancer: A Focus on Metal Complexes.

IF 3.3 3区医学 Q2 CHEMISTRY, MEDICINAL

Mini reviews in medicinal chemistry Pub Date : 2025-06-05 DOI:10.2174/0113895575370547250526062144

Amos Olalekan Akinyemi, Josias da Silveira Rocha, Gabriela Porto de Oliveira, Josenilton de Jesus Santos, Bolaji C Dayo Owoyemi, Fillipe Vieira Rocha

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引用次数: 0

Abstract

DNA topoisomerases, particularly type II, are crucial for DNA processes, such as replication, transcription, and chromosome segregation, making them prime targets for cancer therapy. This review delves into the multifaceted mechanisms of action of type II topoisomerases, highlighting their essential roles beyond cancer progression. It explores recent advancements in screening and designing metallic complexes as inhibitors of topoisomerase II activity. Emphasizing the structural and functional diversity between alpha and beta isoforms, it elucidates their significance in DNA metabolism and genome integrity. Additionally, this review discusses the interplay of topoisomerase II with cellular components, underscoring its regulatory roles in gene expression. Insights into screening and design strategies for metallic complex inhibitors are provided, showcasing their therapeutic potential against cancer. Overall, this review highlights the importance of understanding topoisomerase II inhibition mechanisms and the versatility of metallic complexes in biomedical research, paving the way for novel therapeutic strategies and broader applications beyond cancer therapy.

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拓扑异构酶II在癌症中的抑制作用：金属配合物的焦点。

DNA拓扑异构酶，特别是II型，对DNA过程至关重要，如复制、转录和染色体分离，使其成为癌症治疗的主要目标。这篇综述深入探讨了II型拓扑异构酶的多方面作用机制，强调了它们在癌症进展之外的重要作用。它探讨了筛选和设计金属配合物作为拓扑异构酶II活性抑制剂的最新进展。强调α和β亚型之间的结构和功能多样性，阐明了它们在DNA代谢和基因组完整性中的意义。此外，本文还讨论了拓扑异构酶II与细胞组分的相互作用，强调了其在基因表达中的调节作用。提供了金属复合物抑制剂的筛选和设计策略的见解，展示了它们对癌症的治疗潜力。总之，这篇综述强调了了解拓扑异构酶II抑制机制和金属配合物在生物医学研究中的多功能性的重要性，为新的治疗策略和癌症治疗以外的更广泛应用铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mini reviews in medicinal chemistry 医学-医药化学

CiteScore

7.80

自引率

0.00%

发文量

231

审稿时长

6 months

期刊介绍： The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines. Mini-Reviews in Medicinal Chemistry covers all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.