Exploring the association between relative fat mass and psoriasis risk: insights from the NHANES data.

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Lipids in Health and Disease Pub Date : 2025-06-09 DOI:10.1186/s12944-025-02615-5

Zeru Chen, Haiwei Chen, Xiaotong Chen, Yuling Chen, Jintong Wang, Yuhua Ou

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引用次数: 0

Abstract

Background: Patients' quality of life is greatly impacted by psoriasis, a prevalent chronic inflammatory skin condition that is frequently linked to a number of systemic disorders. Recent research shows that obesity is a major risk factor for psoriasis. Since Relative Fat Mass (RFM), an innovative way to measure obesity, offers a more precise estimate of body fat percentage, this study aims to investigate the connection between RFM and psoriasis and its potential as a disease predictor.

Methods: The analysis included 6,006 people the National Health and Nutrition Examination Survey (NHANES) conducted between 2003 and 2006, 151 of whom had psoriasis. Weighted multivariable logistic regression, restricted cubic splines (RCS), subgroup analysis, and interaction tests were employed to assess the link between RFM and psoriasis. ROC curves were used to compare RFM with conventional measures of obesity (WWI, BRI). Furthermore, LASSO regression and multivariable regression based on AIC were used to create a psoriasis risk prediction model that included RFM and additional clinical factors.

Results: RFM and psoriasis risk were revealed to be significantly positively correlated. The chance of developing psoriasis increased by 7% for every unit rise in RFM (95% CI: 1.03 to 1.12). RFM showed better predictive ability than conventional markers including BMI, WWI, and BRI (AUC = 0.573). The RFM-psoriasis relationship and diabetes status significantly interacted, with the association being weaker in diabetic individuals, according to subgroup analysis and interaction tests. Promising results were obtained from the created psoriasis risk prediction model that included RFM, age, total dietary sugar, education level, history of heart disease, and hypertension.

Conclusion: This research demonstrates that RFM outperforms traditional anthropometric methods in predicting risk. It also presents the initial evidence establishing a positive link between RFM and the likelihood of developing psoriasis.The psoriasis risk prediction model underscores RFM's effectiveness as a valuable approach in both clinical and public health domains, aiming to alleviate the impact of psoriasis-related issues by offering a practical instrument for early risk assessment and personalized clinical strategies.

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探索相对脂肪量与牛皮癣风险之间的关系：来自NHANES数据的见解。

背景：牛皮癣是一种常见的慢性炎症性皮肤病，经常与许多全身疾病有关，严重影响患者的生活质量。最近的研究表明，肥胖是牛皮癣的主要危险因素。由于相对脂肪质量（RFM）是一种衡量肥胖的创新方法，可以更精确地估计体脂百分比，因此本研究旨在调查RFM与牛皮癣之间的联系及其作为疾病预测因子的潜力。方法：分析2003 ~ 2006年全国健康与营养调查（NHANES）的6006人，其中151人患有牛皮癣。采用加权多变量logistic回归、限制性三次样条（RCS）、亚组分析和相互作用检验来评估RFM与牛皮癣之间的联系。ROC曲线用于比较RFM与常规肥胖测量（WWI， BRI）。利用LASSO回归和基于AIC的多变量回归建立了包括RFM和其他临床因素的银屑病风险预测模型。结果：RFM与银屑病风险呈显著正相关。RFM每增加一个单位，患牛皮癣的机会增加7% （95% CI: 1.03至1.12）。RFM的预测能力优于BMI、WWI、BRI等常规指标（AUC = 0.573）。根据亚组分析和相互作用试验，rfm -牛皮癣关系和糖尿病状态显著相互作用，糖尿病个体的相关性较弱。建立的牛皮癣风险预测模型包括RFM、年龄、总膳食糖、教育水平、心脏病史和高血压，结果令人满意。结论：本研究表明RFM在预测风险方面优于传统的人体测量方法。它还提出了初步证据，建立了RFM和发展银屑病的可能性之间的积极联系。牛皮癣风险预测模型强调了RFM在临床和公共卫生领域的有效性，旨在通过提供早期风险评估和个性化临床策略的实用工具来减轻牛皮癣相关问题的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.