Molecular biomarkers for the prognosis of breast cancer: role of amino acid metabolism genes.

IF 3.7 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of physiology and biochemistry Pub Date : 2025-06-10 DOI:10.1007/s13105-025-01088-5

Yudong Zhou, Shibo Yu, Lizhe Zhu, Yalong Wang, Chenglong Duan, Danni Li, Jinsui Du, Jiaqi Zhang, Jianing Zhang, Ruichao Ma, Jianjun He, Yu Ren, Bin Wang

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引用次数: 0

Abstract

The development of precise molecular biomarkers for breast cancer prognosis holds immense potential to improve treatment outcomes. This study aimed to investigate the role of amino acid metabolism genes as predictive markers for breast cancer prognosis and their association with the immune-tumour microenvironment. By employing advanced machine learning algorithms and bioinformatics analysis techniques, the impact of amino acid metabolism-related genes (AAMRGs) on the immune status and overall survival of patients with breast cancer was examined. An AAMRG-based risk model was established to assess the prognostic significance. Validated risk models (AIMP2, IYD, and QARS1) accurately predicted patient outcomes [1 y: 0.87 (0.96-0.78); 3 y: 0.82 (0.87-0.76); 5 y: 0.80 (0.86-0.75)]. Furthermore, this study revealed evidence suggesting that QARS1 may influence breast cancer cell proliferation through methionine metabolism. This analysis provides valuable insights into the mechanisms of breast cancer, emphasizing the significance of AAMRGs as prognostic biomarkers and potential therapeutic targets for optimizing personalized treatment strategies.

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乳腺癌预后的分子生物标志物：氨基酸代谢基因的作用。

精确的分子生物标志物对乳腺癌预后的发展具有巨大的潜力，可以改善治疗结果。本研究旨在探讨氨基酸代谢基因作为乳腺癌预后预测标志物的作用及其与免疫肿瘤微环境的关系。采用先进的机器学习算法和生物信息学分析技术，研究了氨基酸代谢相关基因（AAMRGs）对乳腺癌患者免疫状态和总体生存的影响。建立基于aamrg的风险模型评估预后意义。经过验证的风险模型（AIMP2、IYD和QARS1）准确预测患者预后[1 y: 0.87 (0.96-0.78)；3 y: 0.82 (0.87-0.76)；5 y: 0.80(0.86-0.75)]。此外，本研究揭示了QARS1可能通过蛋氨酸代谢影响乳腺癌细胞增殖的证据。该分析为乳腺癌的机制提供了有价值的见解，强调了AAMRGs作为预后生物标志物和优化个性化治疗策略的潜在治疗靶点的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of physiology and biochemistry 生物-生化与分子生物学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of Physiology and Biochemistry publishes original research articles and reviews describing relevant new observations on molecular, biochemical and cellular mechanisms involved in human physiology. All areas of the physiology are covered. Special emphasis is placed on the integration of those levels in the whole-organism. The Journal of Physiology and Biochemistry also welcomes articles on molecular nutrition and metabolism studies, and works related to the genomic or proteomic bases of the physiological functions. Descriptive manuscripts about physiological/biochemical processes or clinical manuscripts will not be considered. The journal will not accept manuscripts testing effects of animal or plant extracts.