Changes in characteristics and HIV-clinical outcomes of pregnant people living with HIV in the UK.

IF 2.8 3区医学 Q2 INFECTIOUS DISEASES

HIV Medicine Pub Date : 2025-06-10 DOI:10.1111/hiv.70056

H Okhai, A Baskaran, L Bukasa, H Peters, C Thorne, C Sabin

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引用次数: 0

Abstract

Objective: In this study, we explore changes in the demographic and clinical characteristics of pregnant people living with HIV, and their post-partum HIV outcomes between 2000 and 2018.

Methods: We described pregnancies resulting in a live birth from the linked UK CHIC/ISOSS dataset in three calendar periods (2000-2006; 2007-2012; 2013-2018). Thereafter, we explored median CD4 count change and viral rebound from delivery to 12 months post-partum.

Results: In total, 4341 pregnancies were included. Maternal age increased from 31 (IQR: 28-35) years in 2000-2006 to 34 (IQR: 30-37) years in 2013-2018. Those conceiving in the most recent period had been diagnosed with HIV for longer (2000-2006: 3.0 years to 2013-2018: 7.5 years), had a higher median CD4 count (431-583 cells/mm³), and median nadir CD4 count (219-260 cells/mm³); they were also more likely to have initiated ART prior to estimated conception (70.1%-92.3%), and have a suppressed conception viral loads (VL) (56.6%-82.0%). There was no difference in median CD4 count change over the three calendar periods (2000-2006: +60 [IQR: -44, +179]; 2007-2012: +51 [-45, +172]; 2013-2018: +28 [-100, +175] cells/mm³; p = 0.12). The cumulative proportion of people with viral rebound at 12 months post-delivery was reduced in 2013-2018 (8.2%) when compared with previous periods (2000-2006: 28.1%; 2007-2012: 19.5%).

Conclusion: Clinical management of pregnant people has changed over time, resulting in positive trends in this study both within pregnancy and post-partum. Further work needs to understand what barriers remain for those who do not achieve optimal management of HIV in the post-partum period.

查看原文本刊更多论文

英国携带HIV的孕妇的特征和HIV临床结果的变化。

目的：在本研究中，我们探讨2000年至2018年期间艾滋病毒感染孕妇的人口统计学和临床特征及其产后艾滋病毒结局的变化。方法：我们描述了来自英国CHIC/ISOSS数据集的三个日历期(2000-2006；2007 - 2012;2013 - 2018)。此后，我们探讨中位CD4计数变化和病毒反弹从分娩到产后12个月。结果：共纳入4341例妊娠。产妇年龄从2000-2006年的31岁（IQR: 28-35）增加到2013-2018年的34岁（IQR: 30-37）。在最近一段时间内怀孕的妇女被诊断患有艾滋病毒的时间更长（2000-2006年：3.0年至2013-2018年：7.5年），CD4细胞计数中位数较高（431-583个细胞/mm3）， CD4细胞计数中位数最低（219-260个细胞/mm3）；他们也更有可能在估计受孕前开始抗逆转录病毒治疗（70.1%-92.3%），并且怀孕病毒载量（VL）受到抑制（56.6%-82.0%）。在三个日历期间，中位CD4计数变化无差异(2000-2006年：+60 [IQR: -44， +179]；2007-2012: +51 [-45, +172]；2013-2018: +28 [-100, +175] cells/mm3；p = 0.12)。2013-2018年，分娩后12个月病毒反弹患者的累计比例（8.2%）与前几期相比有所下降(2000-2006年：28.1%；2007 - 2012: 19.5%)。结论：随着时间的推移，孕妇的临床管理发生了变化，导致本研究在妊娠期和产后都有积极的趋势。进一步的工作需要了解，对于那些在产后期间没有实现最佳艾滋病毒管理的人来说，仍然存在哪些障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

HIV Medicine 医学-传染病学

CiteScore

5.10

自引率

10.00%

发文量

167

审稿时长

6-12 weeks

期刊介绍： HIV Medicine aims to provide an alternative outlet for publication of international research papers in the field of HIV Medicine, embracing clinical, pharmocological, epidemiological, ethical, preclinical and in vitro studies. In addition, the journal will commission reviews and other feature articles. It will focus on evidence-based medicine as the mainstay of successful management of HIV and AIDS. The journal is specifically aimed at researchers and clinicians with responsibility for treating HIV seropositive patients.