Associations Between Age, Chronic Pain, Cognitive Function, and Pain Sensitivity: A Comparison of Older and Younger Adults.

Abstract

The aim of this study was to examine the associations between age, chronic pain, cognitive function, and pain sensitivity by comparing older and younger adults. The study included 30 older adults with chronic pain, 31 older adults without pain, 26 young adults with chronic pain, and 31 young adults without pain. Cognitive functions were assessed using the Mini-Mental State Examination, Stroop Test, and Clock Drawing Test. Pressure pain thresholds (PPT) were measured in the trapezius, deltoid, and tibialis anterior regions using an algometer. Significant differences were observed in most cognitive functions and PPTs between the groups, particularly between older adults with and without chronic pain, and young adults with and without chronic pain. Generally, moderate to strong negative correlations were found between pain sensitivity and cognitive performance in older adults with chronic pain. In contrast, young adults with chronic pain showed weaker and fewer correlations between pain sensitivity and cognitive function. Chronic pain has a more significant negative impact on cognitive function in older adults, who also exhibit stronger associations between pain sensitivity and cognitive decline. In contrast, younger adults with chronic pain demonstrate weaker correlations, potentially due to adaptive coping mechanisms. These findings highlight the need for age-specific interventions targeting both pain and cognitive decline in older populations.