Development, characterization and in vitro evaluation of capecitabine-loaded chitosan nanoparticles.

IF 2.4 4区医学 Q3 CHEMISTRY, MEDICINAL

Drug Development and Industrial Pharmacy Pub Date : 2025-06-13 DOI:10.1080/03639045.2025.2518304

Debarati Ghosh, Ketousetuo Kuotsu

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引用次数: 0

Abstract

Objective: To formulate capecitabine-loaded nanoparticles by the ionotropic gelation method, using low molecular weight (LMW) chitosan polymer and sodium tripolyphosphate (STPP) as the cross-linking agent.

Methods: Nanoparticles were prepared using the ionotropic gelation method. They were characterized for particle size, polydispersity index (PDI), entrapment efficiency (%), and percentage yield (%) using dynamic light scattering (DLS), UV-Visible spectrophotometry, and other analytical techniques.

Results: The optimized formulation (CN-4) showed a particle size of 166.5 nm ± 2.3 nm, PDI of 0.346 ± 0.01, entrapment efficiency of 65.34 ± 1.8%, and percentage yield of 90.32 ± 2.1%. The zeta potential of CN-4 was found to be +37.4 mV, confirming its colloidal stability and cationic surface characteristics. An increase in particle size and PDI was observed with higher concentrations of chitosan.

Conclusions: No appreciable difference in particle size, polydispersity index (PDI) and percentage intensity was observed for CN-4 formulation after storing it for a period of 15 days at 2-4 °C. However, significant changes were observed after 30 days of storage, indicating destabilization and precipitation of the formulation.

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卡培他滨负载壳聚糖纳米颗粒的制备、表征及体外评价。

目的：以低分子量壳聚糖（LMW）聚合物和三聚磷酸钠（STPP）为交联剂，采用离子化凝胶法制备负载卡培他滨纳米颗粒。方法：采用离子化凝胶法制备纳米颗粒。采用动态光散射（DLS）、紫外可见分光光度法和其他分析技术对其粒度、多分散性指数（PDI）、包封效率（%）和产率（%）进行表征。结果：优化后的CN-4的粒径为166.5 nm±2.3 nm， PDI为0.346±0.01，包封效率为65.34±1.8%，收率为90.32±2.1%。发现CN-4的zeta电位为+37.4 mV，证实了其胶体稳定性和阳离子表面特性。壳聚糖浓度越高，粒径越大，PDI越大。结论：CN-4制剂在2-4℃条件下保存15 d后，其粒径、多分散性指数（PDI）和百分比强度均无明显差异。然而，30天后观察到显著的变化，表明制剂不稳定和沉淀。

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来源期刊

Drug Development and Industrial Pharmacy 医学-药学

CiteScore

6.80

自引率

0.00%

发文量

审稿时长

4.5 months

期刊介绍： The aim of Drug Development and Industrial Pharmacy is to publish novel, original, peer-reviewed research manuscripts within relevant topics and research methods related to pharmaceutical research and development, and industrial pharmacy. Research papers must be hypothesis driven and emphasize innovative breakthrough topics in pharmaceutics and drug delivery. The journal will also consider timely critical review papers.