Sex Difference of Alcoholic Hypertension: Mechanism and Targeted Therapy.

IF 3.9 2区医学 Q1 PERIPHERAL VASCULAR DISEASE

Current Hypertension Reports Pub Date : 2025-06-10 DOI:10.1007/s11906-025-01334-7

Lu Xiao, Sicong Yang, Yali Song, Jia Xiao

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Abstract

Purpose of review: This review provides a critical examination of the sex-specific impact of alcohol consumption on the development and progression of hypertension. Specifically, it elucidates the differential roles of alcohol metabolism and blood pressure regulatory mechanisms in men and women. Finally, it explores promising sex-specific therapeutic strategies for the management of alcoholic hypertension.

Recent findings: Emerging evidence indicates significant sex-based disparities in alcohol pharmacokinetics and pharmacodynamics, with women exhibiting heightened susceptibility to alcohol-induced cardiovascular sequelae. Crucially, key mechanistic insights reveal the differential modulation of the renin-angiotensin-aldosterone system (RAAS), oxidative stress pathways, and the intricate interplay of sex hormones, including the protective effects of estrogen and the potential pro-hypertensive effects of testosterone. Consequently, contemporary therapeutic avenues are increasingly focusing on targeting these sex-specific pathophysiological mechanisms. Alcoholic hypertension manifests with distinct sex-related etiologies and underlying mechanisms, necessitating the development of tailored therapeutic interventions. Effective management strategies should prioritize addressing sex-specific differences in oxidative stress, RAAS activation, and the implementation of personalized lifestyle modifications.

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酒精性高血压的性别差异：机制和靶向治疗。

综述目的：本综述对饮酒对高血压发生和发展的性别特异性影响进行了批判性研究。具体来说，它阐明了酒精代谢和血压调节机制在男性和女性中的不同作用。最后，它探讨了酒精性高血压管理的有希望的性别特异性治疗策略。最新发现：新出现的证据表明，酒精药代动力学和药效学存在显著的性别差异，女性对酒精引起的心血管后遗症表现出更高的易感性。至关重要的是，关键的机制揭示了肾素-血管紧张素-醛固酮系统（RAAS）的差异调节、氧化应激途径和性激素的复杂相互作用，包括雌激素的保护作用和睾酮的潜在促高血压作用。因此，当代的治疗途径越来越多地集中在针对这些性别特异性病理生理机制。酒精性高血压表现出不同的与性别相关的病因和潜在机制，需要开发量身定制的治疗干预措施。有效的管理策略应优先解决氧化应激、RAAS激活的性别差异，并实施个性化的生活方式改变。

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来源期刊

Current Hypertension Reports 医学-外周血管病

CiteScore

10.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of hypertension. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antihypertensive therapies, associated metabolic disorders, and therapeutic trials. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.