A Retrospective Observational Study of the Incidence and Associated Risk Factors of Skin Cancers in Renal Transplant Recipients in Canterbury, New Zealand

IF 1.8 4区医学 Q2 DERMATOLOGY

Australasian Journal of Dermatology Pub Date : 2025-06-10 DOI:10.1111/ajd.14538

Julia (Xiaoyu) Zhu, Eve Mallon, Caroline Mahon, Nicholas Cross, Amanda Oakley

{"title":"A Retrospective Observational Study of the Incidence and Associated Risk Factors of Skin Cancers in Renal Transplant Recipients in Canterbury, New Zealand","authors":"Julia (Xiaoyu) Zhu, Eve Mallon, Caroline Mahon, Nicholas Cross, Amanda Oakley","doi":"10.1111/ajd.14538","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Skin cancer is a significant complication amongst renal transplant recipients, associated with substantial morbidity and mortality.</p>\n </section>\n \n <section>\n \n <h3> Aim</h3>\n \n <p>This retrospective observational study aimed to assess the incidence and identify associated risk factors for skin cancers amongst renal transplant recipients in Canterbury, New Zealand.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>We retrospectively reviewed data from 177 renal transplant recipients who underwent transplantation between January 2004 and December 2015.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Amongst the patients, 32% developed skin cancers. The mean age of the study cohort is 57 years with a mean age at transplant of 47 years. A total of 315 histologically proven invasive skin cancers were recorded, with a squamous cell carcinoma (SCC) to basal cell carcinoma (BCC) ratio of 1.25:1. Forty-four patients had died by the study's conclusion, with metastatic skin cancer accounting for four deaths (9%). Non-melanoma skin cancers (NMSC) showed significant associations with older age and older age at transplant (<i>p</i> < 0.001). Male gender, skin phototype I-III, and ciclosporin exposure were also associated with increased NMSC risk (<i>p</i> < 0.05). The cumulative 10-year risk for NMSC amongst renal transplant recipients was estimated at 28.85% (95% CI = 28.77–28.91).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>This study confirms a high incidence of skin cancers amongst renal transplant recipients in Canterbury, New Zealand, consistent with international findings. Understanding the risk factors for skin cancer can aid in developing targeted strategies for prevention and management in transplant recipients.</p>\n </section>\n </div>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":"66 6","pages":"350-358"},"PeriodicalIF":1.8000,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Australasian Journal of Dermatology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/ajd.14538","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Skin cancer is a significant complication amongst renal transplant recipients, associated with substantial morbidity and mortality.

Aim

This retrospective observational study aimed to assess the incidence and identify associated risk factors for skin cancers amongst renal transplant recipients in Canterbury, New Zealand.

Methods

We retrospectively reviewed data from 177 renal transplant recipients who underwent transplantation between January 2004 and December 2015.

Results

Amongst the patients, 32% developed skin cancers. The mean age of the study cohort is 57 years with a mean age at transplant of 47 years. A total of 315 histologically proven invasive skin cancers were recorded, with a squamous cell carcinoma (SCC) to basal cell carcinoma (BCC) ratio of 1.25:1. Forty-four patients had died by the study's conclusion, with metastatic skin cancer accounting for four deaths (9%). Non-melanoma skin cancers (NMSC) showed significant associations with older age and older age at transplant (p < 0.001). Male gender, skin phototype I-III, and ciclosporin exposure were also associated with increased NMSC risk (p < 0.05). The cumulative 10-year risk for NMSC amongst renal transplant recipients was estimated at 28.85% (95% CI = 28.77–28.91).

Conclusion

This study confirms a high incidence of skin cancers amongst renal transplant recipients in Canterbury, New Zealand, consistent with international findings. Understanding the risk factors for skin cancer can aid in developing targeted strategies for prevention and management in transplant recipients.

查看原文本刊更多论文

新西兰坎特伯雷肾移植受者皮肤癌发病率及相关危险因素的回顾性观察研究

背景：皮肤癌是肾移植受者中一个重要的并发症，具有很高的发病率和死亡率。目的：本回顾性观察性研究旨在评估新西兰坎特伯雷肾移植受者皮肤癌的发生率并确定相关危险因素。方法：回顾性分析2004年1月至2015年12月177例肾移植受者的资料。结果：32%的患者发生皮肤癌。研究队列的平均年龄为57岁，移植时的平均年龄为47岁。共记录了315例组织学证实的浸润性皮肤癌，鳞状细胞癌（SCC）与基底细胞癌（BCC）的比例为1.25:1。到研究结论时，已有44名患者死亡，其中转移性皮肤癌占4例死亡（9%）。非黑色素瘤皮肤癌（NMSC）显示出与年龄和移植年龄的显著关联(p结论：本研究证实了新西兰坎特伯雷肾移植受者中皮肤癌的高发病率，与国际研究结果一致。了解皮肤癌的危险因素有助于制定有针对性的策略来预防和管理移植受者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Australasian Journal of Dermatology 医学-皮肤病学

CiteScore

3.20

自引率

5.00%

发文量

186

审稿时长

6-12 weeks

期刊介绍： Australasian Journal of Dermatology is the official journal of the Australasian College of Dermatologists and the New Zealand Dermatological Society, publishing peer-reviewed, original research articles, reviews and case reports dealing with all aspects of clinical practice and research in dermatology. Clinical presentations, medical and physical therapies and investigations, including dermatopathology and mycology, are covered. Short articles may be published under the headings ‘Signs, Syndromes and Diagnoses’, ‘Dermatopathology Presentation’, ‘Vignettes in Contact Dermatology’, ‘Surgery Corner’ or ‘Letters to the Editor’.